{"id":"W2592754872","doi":"10.1186/s13223-017-0184-y","title":"Gene therapy for primary immune deficiencies: a Canadian perspective","year":2017,"lang":"en","type":"review","venue":"Allergy Asthma and Clinical Immunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Genetic enhancement; Adenosine deaminase deficiency; Immune system; Ex vivo; Chronic granulomatous disease; Adenosine deaminase; Gene delivery; Haematopoiesis; Immunology; Primary immunodeficiency; Stem cell; Severe combined immunodeficiency; Medicine; T cell; Biology; Cancer research; Gene; In vivo; Internal medicine; Adenosine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007630247,0.0007061808,0.0007746315,0.002431351,0.00043042,0.001044302,0.0007379527,0.001428522,0.003623465],"category_scores_gemma":[0.0008662872,0.0002122337,0.0003603234,0.002469393,0.0008558554,0.00148809,0.0006018991,0.002457843,0.001730062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002026075,"about_ca_system_score_gemma":0.003213103,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01121728,"about_ca_topic_score_gemma":0.02269755,"domain_scores_codex":[0.9997768,0.00003007043,0.0000242005,0.00003103467,0.0001144348,0.0000235644],"domain_scores_gemma":[0.9995537,0.0001404894,0.00003897111,0.000009929196,0.0001976871,0.00005914144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006962349,0.00005717865,0.0002015199,0.009963896,0.00004704608,0.000363567,0.0001407215,0.0003770605,0.00248288,0.01057581,0.09906444,0.8766562],"study_design_scores_gemma":[0.000005599611,0.00002472038,0.000244607,0.001172303,0.00002110721,0.0006173092,0.00003587764,0.00003233605,0.0001980402,0.0008712718,0.9967686,0.000008207411],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004534,0.9974521,0.0000938888,0.0008135893,0.0004769951,0.000001891523,0.000007715863,0.000005084514,0.001103403],"genre_scores_gemma":[0.000307091,0.9983966,0.00009979813,0.0003395198,0.0002022633,0.000001956488,0.000008537485,0.000001368702,0.000642915],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9887827,"threshold_uncertainty_score":0.02230394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08112059005269065,"score_gpt":0.4135668593249015,"score_spread":0.3324462692722109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}