{"id":"W2592759934","doi":"10.1182/blood.v104.11.1975.1975","title":"The Oncogenic Potential of the Homeobox Gene Cdx2 Is Depending on the MAPK Pathway and Can Be Antagonized by the MEK1/2 Inhibitor PD98059 in a Mouse Model of t(12;13)(p13;q12) Positive AML.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CDX2; Ectopic expression; Biology; Homeobox; Progenitor cell; Cancer research; Molecular biology; Mutant; Fusion gene; Cell biology; Gene expression; Stem cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376487,0.0004799501,0.0002675448,0.0003350711,0.0001460329,0.0003365276,0.0002278581,0.0003603809,0.001899158],"category_scores_gemma":[0.00008559109,0.0001785341,0.0002989176,0.0001461989,0.0003555111,0.0002143348,0.0002072984,0.001153839,0.0004629468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002697799,"about_ca_system_score_gemma":0.0002010093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004474321,"about_ca_topic_score_gemma":0.0008079485,"domain_scores_codex":[0.9997911,0.00003403519,0.0000180096,0.00003243593,0.00005881751,0.00006557821],"domain_scores_gemma":[0.9998688,0.00001758012,0.00003453203,0.00001268913,0.000006401694,0.00005998888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003699656,0.0001303425,0.0001347108,0.00002059735,0.000004037211,0.0000845396,0.00001145361,0.00009139123,0.9980618,0.0002134547,0.00006734654,0.0008102554],"study_design_scores_gemma":[0.0000571133,0.0006473362,0.002256226,0.00000656775,0.00001148821,0.0002723458,0.00002403208,0.001224452,0.9936127,0.00006087586,0.00182339,0.000003477975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995775,0.0004781413,0.0012691,0.0001006641,0.00003935338,0.00004124222,0.0006015568,0.00009985345,0.001594923],"genre_scores_gemma":[0.9921467,0.0003834772,0.00137472,0.00003346679,0.00000752561,0.00009544464,0.0006381369,0.00002993302,0.005290539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899158,"threshold_uncertainty_score":0.006353319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00801813846626139,"score_gpt":0.2027655159455168,"score_spread":0.1947473774792554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}