{"id":"W2592819689","doi":"10.1002/pros.23327","title":"IAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration‐Resistant Prostate Cancer Cells via Autocrine TNF‐α Signaling","year":2017,"lang":"en","type":"article","venue":"The Prostate","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"Henry Ford Health System","keywords":"Enzalutamide; Prostate cancer; Apoptosis; Cancer research; LNCaP; Survivin; Clonogenic assay; DU145; Autocrine signalling; XIAP; Inhibitor of apoptosis; Medicine; Androgen receptor; Cancer; Biology; Internal medicine; Programmed cell death; Caspase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008974564,0.0003025805,0.0002380067,0.0001840602,0.00008457174,0.0002262567,0.0001732064,0.0001315838,0.001303141],"category_scores_gemma":[0.00006982687,0.00007632261,0.0001932629,0.0001642006,0.0001095685,0.0001093431,0.00009569794,0.0005223239,0.0004018278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002240337,"about_ca_system_score_gemma":0.0002773476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000502291,"about_ca_topic_score_gemma":0.001058566,"domain_scores_codex":[0.9999192,0.00001350366,0.000009030116,0.00001186384,0.00002287688,0.00002353086],"domain_scores_gemma":[0.999949,0.000007818122,0.0000131163,0.000007147535,0.000007248269,0.0000156471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003842635,0.0001484583,0.0003155573,0.0001103897,0.00001462678,0.00007385983,0.00001464742,0.0001748051,0.9942322,0.00005132805,0.000219366,0.004260516],"study_design_scores_gemma":[0.00008824899,0.001668686,0.004488724,0.00001129634,0.00003265045,0.0003802868,0.00002825779,0.0009164252,0.9879566,0.00002380026,0.004399768,0.000005276756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991227,0.004168488,0.001078193,0.0001214358,0.00004570743,0.00004338377,0.0005380333,0.000127686,0.002650067],"genre_scores_gemma":[0.9930098,0.002153286,0.001412683,0.00007647208,0.00001412826,0.00004442733,0.0008512608,0.00001207915,0.002425926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001303141,"threshold_uncertainty_score":0.004359424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008987010806151541,"score_gpt":0.2833030742095073,"score_spread":0.2743160634033558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}