{"id":"W2592819689","doi":"10.1002/pros.23327","title":"IAP Antagonists Enhance Apoptotic Response to Enzalutamide in Castration‐Resistant Prostate Cancer Cells via Autocrine TNF‐α Signaling","year":2017,"lang":"en","type":"article","venue":"The Prostate","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"Henry Ford Health System","keywords":"Enzalutamide; Prostate cancer; Apoptosis; Cancer research; LNCaP; Survivin; Clonogenic assay; DU145; Autocrine signalling; XIAP; Inhibitor of apoptosis; Medicine; Androgen receptor; Cancer; Biology; Internal medicine; Programmed cell death; Caspase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006739069,0.0001905613,0.0001536876,0.000044288,0.0004050299,0.000139498,0.000298024,0.00006862049,0.00001722457],"category_scores_gemma":[0.00005851335,0.0001447783,0.00005362295,0.00006404887,0.00008379387,0.00001258772,0.0001560729,0.0001068791,0.00001790329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005157322,"about_ca_system_score_gemma":0.0001321541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003577491,"about_ca_topic_score_gemma":0.0006374441,"domain_scores_codex":[0.9986527,0.0001170038,0.0002824388,0.0003919427,0.0001633889,0.0003925143],"domain_scores_gemma":[0.9989957,0.00001727602,0.0001857808,0.0006286484,0.00008177335,0.00009087771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001864299,0.00003002753,0.0000881843,0.00002516423,0.00001537409,0.00001456213,0.0005243131,0.004812283,0.9873094,0.00002028444,0.00006386279,0.005232268],"study_design_scores_gemma":[0.0004817472,0.0002438251,0.006628945,0.0000624677,0.00001413546,0.000005724902,0.00005188223,0.0005783674,0.9869542,0.0002976766,0.004463006,0.0002180147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958504,0.0002637321,0.0008074427,0.001865651,0.0002617078,0.000830853,0.00004832965,0.00001415582,0.00005769595],"genre_scores_gemma":[0.9936794,0.0001971389,0.0008359613,0.0001699853,0.0001221992,0.0001306301,0.00002671291,0.00003088529,0.004807099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00654076,"threshold_uncertainty_score":0.590389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008987010806151541,"score_gpt":0.2833030742095073,"score_spread":0.2743160634033558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}