{"id":"W2592880966","doi":"10.1158/1538-7445.sabcs16-p4-22-03","title":"Abstract P4-22-03: Palbociclib in combination with endocrine therapy in treatment-naive and previously treated elderly women with HR+, HER2– advanced breast cancer: a pooled analysis from randomized phase 2 and 3 studies","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Palbociclib; Fulvestrant; Medicine; Letrozole; Internal medicine; Breast cancer; Metastatic breast cancer; Cancer; Clinical endpoint; Neutropenia; Oncology; Randomized controlled trial; Placebo; Gastroenterology; Gynecology; Chemotherapy; Estrogen receptor; Tamoxifen; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01002281,0.001534865,0.005109042,0.001329647,0.0002746646,0.001685548,0.0008919826,0.001145858,0.003243404],"category_scores_gemma":[0.007105088,0.0007013304,0.009853186,0.001929865,0.0006189063,0.0009753731,0.0006591179,0.001197646,0.0003668803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007784316,"about_ca_system_score_gemma":0.001081662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008296533,"about_ca_topic_score_gemma":0.001910775,"domain_scores_codex":[0.9940413,0.004168612,0.0006636588,0.0005423703,0.0004260524,0.0001580184],"domain_scores_gemma":[0.9955423,0.001804054,0.001701785,0.0002926722,0.0003666115,0.0002925112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.7744662,0.0007352916,0.01247171,0.007060786,0.1678384,0.0001178312,0.00004251967,0.0009492785,0.003668522,0.00005545394,0.001579173,0.03101493],"study_design_scores_gemma":[0.5495554,0.05677537,0.07881793,0.0009212579,0.3052113,0.0003405999,0.0001032622,0.001710703,0.001629813,0.0003192406,0.004523054,0.00009207198],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.793529,0.1860202,0.002953936,0.0008318495,0.0005900333,0.004467817,0.008414236,0.0002949271,0.002897943],"genre_scores_gemma":[0.9783939,0.01401422,0.001349197,0.0006719783,0.0003597039,0.001721473,0.00291797,0.00004101573,0.0005305567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01002281,"threshold_uncertainty_score":0.05300629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410407231845639,"score_gpt":0.4223112440159397,"score_spread":0.3782071716974833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}