{"id":"W2592880966","doi":"10.1158/1538-7445.sabcs16-p4-22-03","title":"Abstract P4-22-03: Palbociclib in combination with endocrine therapy in treatment-naive and previously treated elderly women with HR+, HER2– advanced breast cancer: a pooled analysis from randomized phase 2 and 3 studies","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Palbociclib; Fulvestrant; Medicine; Letrozole; Internal medicine; Breast cancer; Metastatic breast cancer; Cancer; Clinical endpoint; Neutropenia; Oncology; Randomized controlled trial; Placebo; Gastroenterology; Gynecology; Chemotherapy; Estrogen receptor; Tamoxifen; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006047475,0.0004352976,0.001815104,0.0006625237,0.000294432,0.0001242846,0.0001770814,0.00007810912,0.0002016436],"category_scores_gemma":[0.00008808367,0.0002766118,0.00006576499,0.0007433656,0.001122646,0.0004825323,0.00005496618,0.0004052376,9.901012e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00141617,"about_ca_system_score_gemma":0.0003850751,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02496292,"about_ca_topic_score_gemma":0.02011426,"domain_scores_codex":[0.9970297,0.0003010282,0.0004408981,0.0008588338,0.0005683754,0.0008011431],"domain_scores_gemma":[0.9977801,0.0005442789,0.0003005778,0.0006109314,0.0005025311,0.0002615208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3924493,0.0008133489,0.1714146,0.0001164494,0.006333685,0.000364613,0.00843737,0.0000878162,0.00719698,0.00001155887,0.000003109434,0.4127712],"study_design_scores_gemma":[0.5732858,0.003468051,0.4126402,0.001159279,0.0006352609,0.00002375303,0.0037741,0.0001816979,0.003949849,0.0003599997,0.0001203566,0.0004016448],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720466,0.02239119,0.000008217366,0.00239682,0.00001974106,0.002855717,0.0001795426,0.00003921721,0.00006292352],"genre_scores_gemma":[0.9488537,0.0460315,0.0001132796,0.0000476754,0.00006574609,0.004533134,0.00003996923,0.00005785439,0.0002570951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4123696,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04410407231845639,"score_gpt":0.4223112440159397,"score_spread":0.3782071716974833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}