{"id":"W2592942452","doi":"10.1017/s2040174417000125","title":"The influence of<i>in vitro</i>fertilization and embryo culture on the embryo epigenetic constituents and the possible consequences in the bovine model","year":2017,"lang":"en","type":"review","venue":"Journal of Developmental Origins of Health and Disease","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Embryo; In vitro fertilisation; Reproductive technology; Andrology; Infertility; Cryopreservation; Transcriptome; Epigenetics; Blastocyst; Embryo cryopreservation; Cell biology; Biotechnology; Genetics; Embryogenesis; Gene; Gene expression; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00210542,0.0001891716,0.0008299069,0.00007536731,0.0003243796,0.00002508367,0.000231544,0.00007312525,6.670948e-7],"category_scores_gemma":[0.001318675,0.00006558739,0.00008688086,0.0001034423,0.001525468,0.00007186534,0.00004604567,0.0003789372,1.838094e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008757057,"about_ca_system_score_gemma":0.002968195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004418548,"about_ca_topic_score_gemma":0.00001171306,"domain_scores_codex":[0.9979947,0.0005111038,0.0008974104,0.0001882769,0.0002401504,0.0001684178],"domain_scores_gemma":[0.998182,0.0003617062,0.0009512488,0.0002348681,0.000104177,0.0001659813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07526875,0.001783952,0.1578062,0.04414476,0.001137598,0.0002319934,0.01063702,0.00006007283,0.0002174785,0.01142845,0.001022494,0.6962613],"study_design_scores_gemma":[0.01034608,0.001418586,0.8342045,0.03538913,0.001269724,0.001134869,0.003249412,0.0001418743,0.00006683853,0.01004911,0.1020679,0.000661973],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2729727,0.723924,0.000002202655,0.002197199,0.00005124995,0.0007888525,0.00002444386,8.013603e-7,0.00003852584],"genre_scores_gemma":[0.3738138,0.6256761,0.00003553533,0.0004247263,0.00001483648,0.00001296689,0.00000473507,0.000003146894,0.00001413611],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6955993,"threshold_uncertainty_score":0.5620651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06319030888791272,"score_gpt":0.3672282385885168,"score_spread":0.3040379297006041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}