{"id":"W2592942452","doi":"10.1017/s2040174417000125","title":"The influence of<i>in vitro</i>fertilization and embryo culture on the embryo epigenetic constituents and the possible consequences in the bovine model","year":2017,"lang":"en","type":"review","venue":"Journal of Developmental Origins of Health and Disease","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Ministère de l'Agriculture, des Pêcheries et de l'Alimentation","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Biology; Embryo; In vitro fertilisation; Reproductive technology; Andrology; Infertility; Cryopreservation; Transcriptome; Epigenetics; Blastocyst; Embryo cryopreservation; Cell biology; Biotechnology; Genetics; Embryogenesis; Gene; Gene expression; Pregnancy; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009320626,0.0002845291,0.0004400575,0.0003237301,0.0002193561,0.0009282389,0.0003953563,0.0005521528,0.001144334],"category_scores_gemma":[0.0007676767,0.0001230536,0.000430396,0.0003663906,0.0004150609,0.0004443759,0.0003062793,0.0004539426,0.0003869757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005181143,"about_ca_system_score_gemma":0.0004626521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325693,"about_ca_topic_score_gemma":0.001791689,"domain_scores_codex":[0.9993436,0.0002447846,0.00007378893,0.0001268385,0.0001604328,0.00005057794],"domain_scores_gemma":[0.9994572,0.000247469,0.0001424799,0.0000297607,0.00009453288,0.0000285642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000592377,0.00009589436,0.003376574,0.01224935,0.000255315,0.0007337203,0.0003930682,0.001041296,0.8345014,0.002729125,0.003150952,0.140881],"study_design_scores_gemma":[0.00003570597,0.002224221,0.03508117,0.002221176,0.001009815,0.002692142,0.0005769663,0.000962718,0.6013676,0.001349299,0.3523804,0.00009875804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.124647,0.8500468,0.006861283,0.001423921,0.0006591502,0.00006396802,0.0008032299,0.00008159786,0.01541309],"genre_scores_gemma":[0.3978156,0.5891508,0.005300218,0.001531698,0.0002774366,0.00009498554,0.001040737,0.00007217531,0.004716183],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001325693,"threshold_uncertainty_score":0.004929304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06319030888791272,"score_gpt":0.3672282385885168,"score_spread":0.3040379297006041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}