{"id":"W2593024568","doi":"10.4049/jimmunol.1601767","title":"The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Endocannabinoid system; Eicosanoid; Chemistry; Cyclooxygenase; Prostaglandin E2; Biochemistry; Prostaglandin E; Lipid signaling; Metabolite; Prostaglandin E2 receptor; Formyl peptide receptor; Prostaglandin; Receptor; Ethanolamine; Arachidonic acid; Lipase; Pharmacology; Chemotaxis; Enzyme; Biology; Endocrinology; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003661905,0.0004161198,0.0004010138,0.0001342964,0.0001022399,0.0002102667,0.0002182173,0.0002580349,0.00242336],"category_scores_gemma":[0.0002413662,0.0001273873,0.0002951377,0.0001184755,0.0002098163,0.0001633206,0.0002150464,0.0005159739,0.0004953867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504173,"about_ca_system_score_gemma":0.0002812516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006820458,"about_ca_topic_score_gemma":0.0008490935,"domain_scores_codex":[0.9996752,0.0001341871,0.0000288494,0.00002347409,0.00005653202,0.00008186826],"domain_scores_gemma":[0.9998959,0.00003520269,0.00001452801,0.00001740192,0.00001246951,0.00002439298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003253649,0.0005346224,0.0004334154,0.000149088,0.00002673847,0.0001530754,0.00003628721,0.0001125109,0.9873779,0.00007679182,0.0001403284,0.007705581],"study_design_scores_gemma":[0.0004096775,0.007084195,0.01156954,0.00001835052,0.00004792586,0.0004001685,0.0000505348,0.001079334,0.9766718,0.00004284663,0.002618695,0.000006820982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991458,0.004652732,0.001637732,0.0001596223,0.00005390946,0.0001077672,0.0002334215,0.00004741798,0.001649353],"genre_scores_gemma":[0.9957737,0.001332403,0.0008078919,0.00006813926,0.0000240666,0.00004987187,0.0003054195,0.000006199475,0.001632257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00242336,"threshold_uncertainty_score":0.008106887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0180245486222684,"score_gpt":0.2924239507279949,"score_spread":0.2743994021057266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}