{"id":"W2593080449","doi":"10.1016/j.ijbiomac.2017.03.054","title":"Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin","year":2017,"lang":"en","type":"article","venue":"International Journal of Biological Macromolecules","topic":"Protein Hydrolysis and Bioactive Peptides","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Enzyme; Renin–angiotensin system; Kinetics; Chemistry; Enzyme kinetics; Angiotensin-converting enzyme; Enzyme inhibition; Biochemistry; Biology; Endocrinology; Active site; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839929,0.0001356682,0.0001994062,0.0000698037,0.00006930905,0.00008044281,0.0002028881,0.00008258572,0.000006669978],"category_scores_gemma":[0.0003943954,0.00009389136,0.00008535185,0.0000192571,0.0003796793,0.00002120246,0.0001962073,0.0001134046,3.197412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009875148,"about_ca_system_score_gemma":0.00001815558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002916906,"about_ca_topic_score_gemma":0.00001900696,"domain_scores_codex":[0.9991223,0.00006582888,0.0003385301,0.0001929279,0.0001682675,0.0001121708],"domain_scores_gemma":[0.9987174,0.00003273329,0.0006445984,0.0001329062,0.0004047388,0.00006760535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003312921,0.00007163804,0.008272001,0.000003965197,0.000177977,0.00007579337,0.00002483056,0.000009170531,0.9845589,0.0001653719,0.00002859371,0.006280404],"study_design_scores_gemma":[0.0006169956,0.0009219488,0.02744616,0.0001230282,0.00002768123,0.0004835792,0.00006283502,0.00004801739,0.9691643,0.0004890442,0.0004905523,0.0001258346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994572,0.0006950824,0.003482258,0.0009683963,0.00006250656,0.0000635062,0.00002818286,0.000002582123,0.0001255189],"genre_scores_gemma":[0.9944787,0.0003367222,0.004883359,0.0001456661,0.0001144943,0.000002362468,0.00001874774,0.000008330443,0.00001164106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01917416,"threshold_uncertainty_score":0.3828779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617415949365995,"score_gpt":0.2730532720483665,"score_spread":0.2568791125547065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}