{"id":"W2593141613","doi":"10.1371/journal.pone.0172880","title":"Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Wellcome Trust; Consejo Nacional de Ciencia y Tecnología; Banting and Best Diabetes Centre, University of Toronto; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Wellcome; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Fundación IMSS; National Institute of Allergy and Infectious Diseases; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Instituto Mexicano del Seguro Social; National Institutes of Health","keywords":"Locus (genetics); Genetics; Triglyceride; Biology; Computational biology; Geography; Gene; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006303699,0.0004323534,0.0003868315,0.0007507757,0.001048039,0.0005517863,0.0004024426,0.0005062353,0.001828572],"category_scores_gemma":[0.001734569,0.0002973055,0.0005012555,0.0008850038,0.0004267077,0.00009510461,0.0006487358,0.0005473882,0.0001317369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003220964,"about_ca_system_score_gemma":0.0002066415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01190071,"about_ca_topic_score_gemma":0.01327446,"domain_scores_codex":[0.9994552,0.0001598493,0.00003753565,0.0002098436,0.00006660625,0.00007097979],"domain_scores_gemma":[0.9995133,0.0001148463,0.000133633,0.0001295951,0.00004277472,0.00006584576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002700508,0.0001999341,0.9447606,0.00003831342,0.0006855371,0.001539263,0.001565687,0.0002616515,0.03719838,0.0004061014,0.0002103851,0.01043366],"study_design_scores_gemma":[0.00009741739,0.0002008803,0.9963026,0.000006956263,0.0001776482,0.0006546052,0.0002571693,0.0003216978,0.001367529,0.00009278671,0.0005129398,0.000007840001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989647,0.00004174263,0.0006483796,0.00003048495,0.000002769608,0.00001289689,0.0001299485,0.000004605871,0.0001646185],"genre_scores_gemma":[0.9989576,0.00003117517,0.0005881776,0.00002116269,0.000003045171,0.0000131544,0.0001766212,0.00000340883,0.0002055183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01190071,"threshold_uncertainty_score":0.02366292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08098517936696233,"score_gpt":0.2893729813841306,"score_spread":0.2083878020171683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}