{"id":"W2593143217","doi":"10.1016/j.chembiol.2017.02.006","title":"Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells","year":2017,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Engineering and Physical Sciences Research Council; Versus Arthritis; Rosetrees Trust; Arthritis Research UK; Cancer Research UK; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; AbbVie; Janssen Biotech; Innovative Medicines Initiative; Wellcome; Merck; Takeda Pharmaceuticals U.S.A.; Pfizer; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim","keywords":"H3K4me3; Demethylation; Chemistry; Transcription (linguistics); Cell biology; Molecular biology; Cancer research; Biology; DNA methylation; Promoter; Biochemistry; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861596,0.0001288361,0.0001957406,0.00003286034,0.00009007858,0.00000984174,0.00007733802,0.0002855659,0.000004915025],"category_scores_gemma":[0.00007055765,0.000121212,0.00004733267,0.00002293143,0.0002488566,0.000006645074,0.00008382118,0.00006432614,6.544416e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001421215,"about_ca_system_score_gemma":0.00002229027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001556656,"about_ca_topic_score_gemma":0.00001379797,"domain_scores_codex":[0.9991402,0.0000645892,0.0002673304,0.0003173894,0.00006285635,0.0001476125],"domain_scores_gemma":[0.9993254,0.00002256918,0.0002420494,0.0002178093,0.0001296416,0.00006253305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001335023,0.00004637569,0.01667804,0.00006250134,0.00001778943,1.522686e-7,0.0001111675,0.000006158738,0.9807524,0.00003047044,0.00001443693,0.002147029],"study_design_scores_gemma":[0.0005341068,0.0003870636,0.004418427,0.000006601585,0.00003091836,5.951574e-7,0.00001624067,0.0001776088,0.9934837,0.0004972945,0.0003283163,0.000119113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960346,0.002073514,0.001337324,0.00004886508,0.00006063065,0.0002154361,0.00003846932,0.000003592963,0.0001875824],"genre_scores_gemma":[0.9978548,0.0004317912,0.001319725,0.00001134126,0.0001000417,0.000008478743,0.0002031683,0.00001068766,0.00006001277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01273133,"threshold_uncertainty_score":0.4942882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212135825096643,"score_gpt":0.2354638380791759,"score_spread":0.2233424798282095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}