{"id":"W2593143217","doi":"10.1016/j.chembiol.2017.02.006","title":"Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells","year":2017,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Engineering and Physical Sciences Research Council; Versus Arthritis; Rosetrees Trust; Arthritis Research UK; Cancer Research UK; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; AbbVie; Janssen Biotech; Innovative Medicines Initiative; Wellcome; Merck; Takeda Pharmaceuticals U.S.A.; Pfizer; Biotechnology and Biological Sciences Research Council; Boehringer Ingelheim","keywords":"H3K4me3; Demethylation; Chemistry; Transcription (linguistics); Cell biology; Molecular biology; Cancer research; Biology; DNA methylation; Promoter; Biochemistry; Gene expression; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008213568,0.0003446815,0.0003035624,0.0002260355,0.0001228512,0.000150608,0.0002383875,0.0001873921,0.001211676],"category_scores_gemma":[0.00007556763,0.0001190667,0.000223722,0.000161468,0.0001264567,0.00007437848,0.0001424535,0.0003738368,0.0003490322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025543,"about_ca_system_score_gemma":0.0002577291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001382883,"about_ca_topic_score_gemma":0.002564987,"domain_scores_codex":[0.9999049,0.000009731209,0.000006794282,0.00001890828,0.00002590261,0.00003382345],"domain_scores_gemma":[0.9999593,0.000007055691,0.000006932888,0.000005450942,0.000005730517,0.00001551248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001848446,0.00007124534,0.0002217969,0.00004330972,0.00001069164,0.0000326774,0.00001087583,0.0001170072,0.9960037,0.00007040537,0.0001420448,0.003091411],"study_design_scores_gemma":[0.0000173407,0.0003524973,0.002169942,0.000003221613,0.0000119579,0.00008960047,0.000007790881,0.0003700749,0.9939829,0.00001246604,0.00297934,0.000002891839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858075,0.006465218,0.003160303,0.000117599,0.00005292764,0.00005859316,0.0008096902,0.0001837771,0.003344455],"genre_scores_gemma":[0.9911309,0.001818998,0.002070564,0.00006902045,0.00001037614,0.0000392453,0.001260191,0.00001511553,0.003585501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382883,"threshold_uncertainty_score":0.004053473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212135825096643,"score_gpt":0.2354638380791759,"score_spread":0.2233424798282095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}