{"id":"W2593147604","doi":"10.1016/j.tiv.2017.03.001","title":"Aryl hydrocarbon receptor upregulates IL-1β expression in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure","year":2017,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Université Paris Descartes","keywords":"Aryl hydrocarbon receptor; Chemokine; Small interfering RNA; Endothelium; Transcription factor; Proinflammatory cytokine; Cytokine; Cell biology; Chemokine receptor; Immunology; Receptor; Endogeny; Chemistry; Tumor necrosis factor alpha; Inflammation; Biology; Pharmacology; Endocrinology; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001910996,0.0002485657,0.0003765995,0.0003854421,0.0003217183,0.0003493265,0.0001662038,0.0002730284,0.002388045],"category_scores_gemma":[0.0001213624,0.0001870247,0.0004076909,0.0004267165,0.0002404798,0.0002280292,0.0001873032,0.0007788241,0.0006063114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003657002,"about_ca_system_score_gemma":0.0003652951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004942291,"about_ca_topic_score_gemma":0.005378391,"domain_scores_codex":[0.9995726,0.00003514308,0.00004316304,0.00007177643,0.0001030597,0.0001742545],"domain_scores_gemma":[0.9998854,0.00002189037,0.00001828677,0.00002038487,0.00002973432,0.00002432155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004052134,0.000100369,0.0007346632,0.0000370063,0.00001241684,0.0001558371,0.00006659596,0.00004846609,0.9975374,0.00008001612,0.0001252458,0.0006968725],"study_design_scores_gemma":[0.00004766385,0.0003651095,0.02117103,0.000006456226,0.00004241377,0.0003061548,0.000236235,0.0006990219,0.9745504,0.00005436597,0.002508799,0.00001231876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950609,0.0009062291,0.001587229,0.0001278984,0.00007863602,0.00001522483,0.001092523,0.00004605818,0.001085255],"genre_scores_gemma":[0.9916775,0.0009109564,0.001131663,0.0001488349,0.00003168618,0.00007190037,0.00180264,0.00001173341,0.004213122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004942291,"threshold_uncertainty_score":0.009827077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01874286402745849,"score_gpt":0.2550077370857532,"score_spread":0.2362648730582947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}