{"id":"W2593168230","doi":"10.2174/1872208311666170301103722","title":"Virus-Based RNA Silencing Agents and Virus-Derived Expression Vectors as Gene Therapy Vehicles","year":2017,"lang":"en","type":"review","venue":"Recent Patents on Biotechnology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Gene silencing; Biology; RNA interference; Computational biology; Vector (molecular biology); Functional genomics; Genetic enhancement; Genomics; Viral vector; Virus; Gene; Genome; RNA; Biotechnology; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006568037,0.000637494,0.0006967268,0.002903956,0.0002225356,0.001034015,0.000532262,0.001125946,0.003520023],"category_scores_gemma":[0.000559211,0.0002174096,0.000565092,0.001850788,0.0005071466,0.001128818,0.0004574718,0.001044826,0.001650492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006019888,"about_ca_system_score_gemma":0.0007520969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005227059,"about_ca_topic_score_gemma":0.0006986501,"domain_scores_codex":[0.9996811,0.00005944445,0.00004241785,0.00005023256,0.0001384534,0.00002833126],"domain_scores_gemma":[0.9997627,0.0001382925,0.00004459482,0.000007606992,0.0000363946,0.00001041239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000691968,0.000084283,0.0002259563,0.02845993,0.00009162533,0.00058916,0.0001643067,0.0006783396,0.0343473,0.02464128,0.009718759,0.9009298],"study_design_scores_gemma":[0.00001157759,0.0001049186,0.000451856,0.002400207,0.00008551854,0.001686412,0.00005649736,0.0001331818,0.01198016,0.002238117,0.9808333,0.00001827512],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007878505,0.9918778,0.001263298,0.0002784741,0.0002013351,0.00002632531,0.00004647471,0.00001657777,0.005501823],"genre_scores_gemma":[0.004785364,0.9912871,0.001189579,0.0001799503,0.00009715492,0.00003002698,0.00007165237,0.000004576103,0.002354583],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003520023,"threshold_uncertainty_score":0.01177561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1120283645226087,"score_gpt":0.376531697030818,"score_spread":0.2645033325082092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}