{"id":"W2593186175","doi":"10.1021/acs.biochem.6b01071","title":"Influence of the Length and Charge on the Activity of α-Helical Amphipathic Antimicrobial Peptides","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canada Research Chairs; Fonds de recherche du Québec – Nature et technologies; Université Laval; Deutscher Akademischer Austauschdienst; European Molecular Biology Organization","keywords":"Peptide; Chemistry; Amphiphile; Antimicrobial peptides; Membrane; Vesicle; Crystallography; Peptide sequence; Charge (physics); Amino acid; Sequence (biology); Homologous series; Stereochemistry; Biochemistry; Organic chemistry; Physics; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603597,0.0001264488,0.0001967102,0.000009599637,0.0004009139,0.0000167484,0.0004522808,0.000176943,0.00002555346],"category_scores_gemma":[0.0002777489,0.0000730126,0.00009264745,0.00002070415,0.001564573,0.00005204954,0.0002529195,0.0002650842,0.000009269339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008137456,"about_ca_system_score_gemma":0.0000484135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000133561,"about_ca_topic_score_gemma":0.000003685117,"domain_scores_codex":[0.9994417,0.0000489184,0.0001397415,0.0001774435,0.00003174659,0.0001604478],"domain_scores_gemma":[0.9989318,0.0001158361,0.0003002556,0.0005979157,0.00004439407,0.000009802324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007481524,0.00006936144,0.004027406,0.00006170465,0.00004156039,2.657929e-7,0.00007697722,0.000001214397,0.9941175,0.0002758249,0.0009702634,0.0002831264],"study_design_scores_gemma":[0.0002203747,0.00002618608,0.04870768,0.00014552,0.00001644013,0.00001300155,0.00002899299,9.010757e-7,0.9505526,0.00002014722,0.0001903586,0.00007784061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980626,0.00008227009,6.435318e-7,0.0009057415,0.00007320759,0.00009136239,0.00009205989,0.000007687085,0.0006844069],"genre_scores_gemma":[0.9990072,0.00006057023,0.00000411755,0.0001078577,0.00002833862,0.000002666246,0.000002091293,0.000006946122,0.0007801998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04468028,"threshold_uncertainty_score":0.5764736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133427937207298,"score_gpt":0.2308767247407433,"score_spread":0.2175339310200135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}