{"id":"W2593231312","doi":"10.1016/s2352-3018(17)30032-2","title":"Switching from efavirenz, emtricitabine, and tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study","year":2017,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Providence Health Care","funders":"","keywords":"Emtricitabine; Rilpivirine; Tenofovir alafenamide; Efavirenz; Medicine; Regimen; Tolerability; Placebo; Internal medicine; Pharmacology; Virology; Adverse effect; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001510475,0.00158469,0.002548607,0.0004196097,0.0003375656,0.0008677316,0.0008426845,0.001613983,0.005345509],"category_scores_gemma":[0.00154929,0.0006467138,0.001701727,0.0003995289,0.001204254,0.001209175,0.0003328231,0.002708061,0.000792005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008039783,"about_ca_system_score_gemma":0.0007877711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358183,"about_ca_topic_score_gemma":0.002301879,"domain_scores_codex":[0.9992939,0.0003225446,0.00004936217,0.0001272182,0.00005071781,0.000156283],"domain_scores_gemma":[0.9992033,0.0002631776,0.0001493329,0.00008516679,0.00003717742,0.0002619207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9660203,0.01051783,0.0004985853,0.0003295882,0.0006311271,0.0000334907,0.00007483229,0.0003068094,0.003963643,0.00006775586,0.0003324774,0.01722364],"study_design_scores_gemma":[0.8815349,0.1143785,0.002436851,0.00002073684,0.0003275224,0.00003230062,0.0000263956,0.000290488,0.0005159503,0.0001089292,0.0003116034,0.0000157007],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963314,0.001297189,0.0002857147,0.0001742098,0.0001734254,0.0007150805,0.0003330743,0.00004007317,0.0006499498],"genre_scores_gemma":[0.9948221,0.001071261,0.0007319557,0.00045283,0.0002214835,0.0008875457,0.000415952,0.0000163192,0.001380476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005345509,"threshold_uncertainty_score":0.01788259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091660925312644,"score_gpt":0.3013084049091931,"score_spread":0.2803917956560666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}