{"id":"W2593231312","doi":"10.1016/s2352-3018(17)30032-2","title":"Switching from efavirenz, emtricitabine, and tenofovir disoproxil fumarate to tenofovir alafenamide coformulated with rilpivirine and emtricitabine in virally suppressed adults with HIV-1 infection: a randomised, double-blind, multicentre, phase 3b, non-inferiority study","year":2017,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Providence Health Care","funders":"","keywords":"Emtricitabine; Rilpivirine; Tenofovir alafenamide; Efavirenz; Medicine; Regimen; Tolerability; Placebo; Internal medicine; Pharmacology; Virology; Adverse effect; Viral load; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005765366,0.0006402566,0.001364263,0.0002737412,0.000645832,0.0002986216,0.0002820164,0.0001078262,0.00002436353],"category_scores_gemma":[0.0001000939,0.000361854,0.00005670457,0.0003948908,0.000142296,0.0004938516,0.0002595694,0.0005035535,0.00003491577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697653,"about_ca_system_score_gemma":0.0002412177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001748706,"about_ca_topic_score_gemma":0.004108777,"domain_scores_codex":[0.9972467,0.0001126031,0.0006061618,0.0008326881,0.0004915096,0.0007103797],"domain_scores_gemma":[0.9978617,0.0002168103,0.0003643347,0.001056676,0.0001624502,0.0003379706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1974153,0.001679096,0.7882392,0.0001038742,0.0006113592,0.0004998739,0.00790041,0.00005605036,0.000762351,0.000004998389,0.0001283121,0.002599156],"study_design_scores_gemma":[0.3999676,0.001005039,0.5942431,0.0004970545,0.0005776369,0.00004206334,0.0004204025,0.002172612,0.0004800558,0.00001815469,0.000146836,0.0004294373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888252,0.0001344678,0.0002606635,0.003653056,0.00006370989,0.006046716,0.00006740937,0.0001236145,0.0008251817],"genre_scores_gemma":[0.9962749,0.0001374569,0.0009360291,0.0001573651,0.000230802,0.0004706724,0.0001560984,0.00006868171,0.001567926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2025523,"threshold_uncertainty_score":0.9998834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02091660925312644,"score_gpt":0.3013084049091931,"score_spread":0.2803917956560666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}