{"id":"W2593449105","doi":"10.2174/1574892812666170227110842","title":"Activating Mutations of ESR1, BRCA1 and CYP19 Aromatase Genes Confer Tumor Response in Breast Cancers Treated with Antiestrogens","year":2017,"lang":"en","type":"review","venue":"Recent Patents on Anti-Cancer Drug Discovery","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Aromatase; Breast cancer; Cancer research; Antiestrogen; Estrogen receptor; Estrogen receptor alpha; Estrogen; Aromatase inhibitor; Tamoxifen; Cancer; Male breast cancer; Internal medicine; Biology; Oncology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002396036,0.0006065492,0.00123297,0.000225987,0.0001525548,0.00009618021,0.0002913014,0.0002759152,0.000008944773],"category_scores_gemma":[0.00004072749,0.000448607,0.0002300603,0.000200859,0.0002871009,0.00003339534,0.0001218162,0.0003256341,0.00000323948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001598335,"about_ca_system_score_gemma":0.0009523967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003747947,"about_ca_topic_score_gemma":0.0000343901,"domain_scores_codex":[0.9975848,0.0003736726,0.0005642805,0.0007868771,0.0002500602,0.0004403421],"domain_scores_gemma":[0.9982712,0.00006201448,0.0008310832,0.0006162663,0.00008705769,0.0001323753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01147041,0.001781494,0.04095278,0.01528234,0.006522837,0.0006511442,0.0002081853,0.000988134,0.04770843,0.00002888701,0.0009179313,0.8734874],"study_design_scores_gemma":[0.01757995,0.003174827,0.01760965,0.1173174,0.004807342,0.001157703,0.0008911866,0.0001657053,0.1814082,0.000007243119,0.6488417,0.00703909],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5050996,0.4929318,0.000001757783,0.00002310926,0.0000853798,0.0005873209,0.001225003,0.000008407276,0.00003767704],"genre_scores_gemma":[0.08581779,0.9124465,0.00001698516,0.00002167414,0.00006199822,0.0001379189,0.001124448,0.00008831122,0.0002843979],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.8664483,"threshold_uncertainty_score":0.9997966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226970799326206,"score_gpt":0.3206335789187787,"score_spread":0.2883638709255167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}