{"id":"W2593449105","doi":"10.2174/1574892812666170227110842","title":"Activating Mutations of ESR1, BRCA1 and CYP19 Aromatase Genes Confer Tumor Response in Breast Cancers Treated with Antiestrogens","year":2017,"lang":"en","type":"review","venue":"Recent Patents on Anti-Cancer Drug Discovery","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia","keywords":"Aromatase; Breast cancer; Cancer research; Antiestrogen; Estrogen receptor; Estrogen receptor alpha; Estrogen; Aromatase inhibitor; Tamoxifen; Cancer; Male breast cancer; Internal medicine; Biology; Oncology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000154773,0.0001060634,0.0001926473,0.0003927559,0.00008798302,0.0001582668,0.00009296375,0.0001781119,0.001683105],"category_scores_gemma":[0.0003437069,0.00007357401,0.0001705624,0.0002088405,0.000122279,0.00007124161,0.0001163434,0.0002337054,0.0001808488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001148768,"about_ca_system_score_gemma":0.0001100611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001700739,"about_ca_topic_score_gemma":0.0001643349,"domain_scores_codex":[0.999878,0.00002117625,0.00001127525,0.00002499761,0.00004060568,0.00002382842],"domain_scores_gemma":[0.9997311,0.00008040897,0.00007797921,0.00002037329,0.00002968367,0.000060486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002404129,0.0001974433,0.1887459,0.00007152885,0.00006424156,0.001000119,0.0001630176,0.0001647425,0.7985925,0.0001254467,0.000171688,0.008299074],"study_design_scores_gemma":[0.00002661422,0.001524577,0.7893479,0.000008993763,0.000102885,0.006362714,0.0002557843,0.000574274,0.199379,0.0001560481,0.002252083,0.000009208133],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9990068,0.0004182719,0.0001481088,0.00002497955,0.000005204043,0.000004077826,0.0001033847,0.00001140994,0.0002777558],"genre_scores_gemma":[0.9993448,0.0001784662,0.0001002363,0.00001206526,0.000003443143,0.000004214751,0.0001259697,0.000002250576,0.0002285028],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001683105,"threshold_uncertainty_score":0.005630612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03226970799326206,"score_gpt":0.3206335789187787,"score_spread":0.2883638709255167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}