{"id":"W2593464858","doi":"10.1128/mbio.00097-17","title":"The Proximity of Ribosomal Protein Genes to <i>oriC</i> Enhances <i>Vibrio cholerae</i> Fitness in the Absence of Multifork Replication","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Centre National de la Recherche Scientifique; Institut Pasteur; Institut national de la recherche scientifique; Agence Nationale de la Recherche; European Molecular Biology Organization","keywords":"Vibrio cholerae; Biology; Locus (genetics); Gene dosage; Genetics; Gene; Origin of replication; Bacterial artificial chromosome; Ribosome biogenesis; Ribosomal RNA; Replication timing; Genome; Computational biology; Gene expression; Ribosome; RNA; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002828139,0.000685938,0.0005918302,0.000373851,0.0001712711,0.0006207151,0.0005717286,0.0004962989,0.001312236],"category_scores_gemma":[0.0003489259,0.0003524931,0.0004220747,0.0002033717,0.0005355654,0.0001852904,0.0008767971,0.001097153,0.0004650747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005812174,"about_ca_system_score_gemma":0.0003915029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002840125,"about_ca_topic_score_gemma":0.002446063,"domain_scores_codex":[0.9993874,0.00009419548,0.00006193334,0.0001313487,0.0001810081,0.0001441524],"domain_scores_gemma":[0.9991345,0.0001440927,0.0002568079,0.0001569281,0.00008068659,0.0002270863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007750899,0.00002135217,0.0001414975,0.00001671797,0.000003758773,0.00001695585,0.000009234344,0.00003471939,0.9994413,0.00001723041,0.000009581919,0.000209991],"study_design_scores_gemma":[0.00002239484,0.001008287,0.01975165,0.00001541828,0.00003277634,0.0002472995,0.0001411483,0.001406341,0.9761126,0.00003878296,0.001197341,0.000026016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980838,0.0002950261,0.0008132216,0.00006645894,0.0000188481,0.00001402552,0.0001984332,0.00006587632,0.0004442843],"genre_scores_gemma":[0.9973769,0.0001166395,0.0008036227,0.0000407698,0.000006329922,0.00001356976,0.0003522037,0.00005260079,0.001237434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002840125,"threshold_uncertainty_score":0.005647123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288099123024142,"score_gpt":0.2650301623423413,"score_spread":0.2521491711120999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}