{"id":"W2593464858","doi":"10.1128/mbio.00097-17","title":"The Proximity of Ribosomal Protein Genes to <i>oriC</i> Enhances <i>Vibrio cholerae</i> Fitness in the Absence of Multifork Replication","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Commission; Centre National de la Recherche Scientifique; Institut Pasteur; Institut national de la recherche scientifique; Agence Nationale de la Recherche; European Molecular Biology Organization","keywords":"Vibrio cholerae; Biology; Locus (genetics); Gene dosage; Genetics; Gene; Origin of replication; Bacterial artificial chromosome; Ribosome biogenesis; Ribosomal RNA; Replication timing; Genome; Computational biology; Gene expression; Ribosome; RNA; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003771281,0.00009201947,0.000115765,0.0000134614,0.0001584518,0.00003416373,0.0008475427,0.0001443619,9.620502e-7],"category_scores_gemma":[0.0001713398,0.00005626538,0.0000450978,0.00006117692,0.0002407961,0.000003983677,0.0002040267,0.0000661118,0.000001436175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003703191,"about_ca_system_score_gemma":0.00003624331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001519985,"about_ca_topic_score_gemma":0.0003933117,"domain_scores_codex":[0.9992043,0.00004298715,0.0002324116,0.0002649028,0.00009773045,0.0001576971],"domain_scores_gemma":[0.9984278,0.000009851186,0.0002376277,0.00122232,0.00008404964,0.00001837004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006398022,0.00004467942,0.002360956,0.00001266029,0.000006865211,2.094987e-7,0.00004212373,0.000002183281,0.979411,0.0001623203,0.00005220821,0.0178408],"study_design_scores_gemma":[0.0001707624,0.0001628182,0.03582389,0.00001830301,0.000002629518,0.000001799225,0.00002818874,0.000007300506,0.9449502,0.00009613141,0.01866636,0.00007158574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997293,0.0003041763,0.0001062876,0.00143525,0.00009694086,0.0005273419,0.00002160293,0.000003151892,0.0002122423],"genre_scores_gemma":[0.9989717,0.0001843656,0.000470647,0.00006073915,0.00008967116,0.00008333848,0.00001068891,0.000006262692,0.0001225666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03446078,"threshold_uncertainty_score":0.2294436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288099123024142,"score_gpt":0.2650301623423413,"score_spread":0.2521491711120999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}