{"id":"W2593551397","doi":"10.7554/elife.21666","title":"A team of heterochromatin factors collaborates with small RNA pathways to combat repetitive elements and germline stress","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Human Frontier Science Program; Darwin Trust of Edinburgh; Cancer Research UK; Wellcome Trust","keywords":"Heterochromatin; Biology; Heterochromatin protein 1; Piwi-interacting RNA; Genetics; Euchromatin; Chromatin; Germline; RNA interference; Epigenetics; Transposable element; Genome; Cell biology; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003280916,0.0008575431,0.0004206787,0.0005336283,0.0005127197,0.0005624179,0.000453896,0.000354194,0.001312268],"category_scores_gemma":[0.0001176424,0.0002242872,0.0005430807,0.0001617991,0.0003218444,0.0002873167,0.0006366325,0.0007528716,0.0005213934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005067475,"about_ca_system_score_gemma":0.0006365633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006656852,"about_ca_topic_score_gemma":0.001077173,"domain_scores_codex":[0.9997044,0.00001887244,0.0000131264,0.0001140317,0.00009526607,0.00005435251],"domain_scores_gemma":[0.9998622,0.000008216333,0.00002534884,0.00002048247,0.00002170601,0.00006205952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006819695,0.00003358909,0.0005131718,0.00003148663,0.00002131049,0.00005948233,0.000009794663,0.0001176395,0.991577,0.0001955649,0.00006974286,0.007302987],"study_design_scores_gemma":[0.0000368065,0.0004370035,0.008235964,0.00001392483,0.00006453868,0.0004056194,0.00003434472,0.002177737,0.9812683,0.0002303153,0.00708361,0.00001172785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947262,0.004552078,0.03795696,0.0004284003,0.0001967255,0.0002761087,0.0003353205,0.0008439319,0.008148521],"genre_scores_gemma":[0.9485896,0.001973454,0.03265598,0.0001834286,0.00004339162,0.0001519755,0.0006128296,0.00006940167,0.01571989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312268,"threshold_uncertainty_score":0.004389942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01253474694172283,"score_gpt":0.2786531702131366,"score_spread":0.2661184232714137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}