{"id":"W2593653166","doi":"","title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.","year":2015,"lang":"en","type":"article","venue":"PMC","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Inflammasome; NLRP1; Caspase 1; Cell biology; Chemistry; AIM2; Caspase 8; Small interfering RNA; Biology; Caspase; Receptor; Programmed cell death; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003049083,0.0002057614,0.0001850593,0.0001141205,0.0001039623,0.0000330638,0.0001156781,0.0001831402,0.00001245462],"category_scores_gemma":[0.0005409614,0.000212766,0.00006149391,0.0001541605,0.0001285554,0.00005471973,0.00009045072,0.0001238682,0.00000472578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000482915,"about_ca_system_score_gemma":0.000192685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004489197,"about_ca_topic_score_gemma":0.00004649882,"domain_scores_codex":[0.9987214,0.0001126207,0.0003710558,0.0003522183,0.0002219451,0.0002207707],"domain_scores_gemma":[0.9989176,0.0000190882,0.0002754128,0.0002614109,0.0004482755,0.00007818924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002580811,0.00007429296,0.01634191,0.00002926768,0.0001073977,9.750161e-7,0.0003428178,0.0006217959,0.9787436,0.000131419,0.002294154,0.001054343],"study_design_scores_gemma":[0.000738119,0.0002459381,0.03493348,0.00004208478,0.00002642173,0.000008667764,0.0002717304,0.0001078119,0.9611836,0.0001011239,0.002113292,0.000227751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984792,0.0001759296,0.00009880533,0.00042252,0.0002209294,0.000271109,0.000009360529,0.00002465912,0.000297441],"genre_scores_gemma":[0.9984468,0.00004661442,0.0001170657,0.00006286303,0.0002163229,0.00003684561,0.0003931973,0.00002929651,0.0006510584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01859157,"threshold_uncertainty_score":0.8676347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521218949710483,"score_gpt":0.225287098373276,"score_spread":0.2100749088761712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}