{"id":"W2593653166","doi":"","title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.","year":2015,"lang":"en","type":"article","venue":"PMC","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Inflammasome; NLRP1; Caspase 1; Cell biology; Chemistry; AIM2; Caspase 8; Small interfering RNA; Biology; Caspase; Receptor; Programmed cell death; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000171984,0.0006396857,0.0003633266,0.0002857467,0.0001794304,0.0004263184,0.0001375829,0.0002288852,0.001134761],"category_scores_gemma":[0.0001260415,0.0001191817,0.0003675364,0.0001636475,0.0002495326,0.0003981445,0.0002759066,0.0006449349,0.0003907873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264361,"about_ca_system_score_gemma":0.0001467813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001111357,"about_ca_topic_score_gemma":0.0001792712,"domain_scores_codex":[0.9997891,0.00002792501,0.00002670324,0.00006218614,0.00005327764,0.00004082154],"domain_scores_gemma":[0.9998683,0.00001065164,0.00005394408,0.00001261634,0.00002651495,0.00002802465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001868298,0.00003037385,0.000561689,0.0001153116,0.00001230943,0.0001183632,0.00003493698,0.00003837882,0.9964076,0.0001097215,0.00007949554,0.002305019],"study_design_scores_gemma":[0.00002873096,0.0003653198,0.02062315,0.00002433254,0.00004850156,0.001265807,0.00007709127,0.0006743775,0.9732101,0.0003435983,0.003330299,0.000008645336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787841,0.01044386,0.006567251,0.0002152365,0.0001013874,0.00005387012,0.001019785,0.0002201659,0.002594253],"genre_scores_gemma":[0.9899277,0.00348695,0.002820631,0.00006034708,0.00002930096,0.00007878515,0.001047106,0.00001801487,0.002531139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001134761,"threshold_uncertainty_score":0.003796101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521218949710483,"score_gpt":0.225287098373276,"score_spread":0.2100749088761712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}