{"id":"W2593688045","doi":"10.1085/jgp.201611668","title":"Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants","year":2017,"lang":"en","type":"article","venue":"The Journal of General Physiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Academy of Sciences; Russian Foundation for Basic Research","keywords":"Chemistry; Sodium channel; Pharmacophore; Stereochemistry; Cationic polymerization; Ion channel; Combinatorial chemistry; Sodium; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001855735,0.0006080681,0.0007200125,0.0002133195,0.0004206632,0.000708811,0.0009579363,0.000530037,0.001777856],"category_scores_gemma":[0.0001458975,0.0002188044,0.0005300172,0.0001463714,0.0008685639,0.0006041221,0.0004238336,0.0004553018,0.0005602505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007438007,"about_ca_system_score_gemma":0.0007182354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001334927,"about_ca_topic_score_gemma":0.0007530916,"domain_scores_codex":[0.9998381,0.00003730602,0.000009855725,0.0000340011,0.00005178475,0.00002894508],"domain_scores_gemma":[0.9999655,0.000005474936,0.00001084771,0.000002847346,0.000005997126,0.000009268056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000591326,0.0002151869,0.005267868,0.001283091,0.0002584215,0.00217552,0.0002637588,0.1686441,0.6752773,0.1123636,0.001948053,0.03171179],"study_design_scores_gemma":[0.0007141603,0.001557909,0.008517476,0.0001486216,0.0002764365,0.00328433,0.0005941734,0.5298413,0.3962741,0.02585313,0.03275254,0.0001857899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.840828,0.0125648,0.1157195,0.001020448,0.0001919236,0.0001970769,0.0005052958,0.001018662,0.02795423],"genre_scores_gemma":[0.9781195,0.006178925,0.01105832,0.0001806069,0.00001649025,0.00008980608,0.0002487043,0.00004331529,0.004064393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001777856,"threshold_uncertainty_score":0.00594753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00988767391229019,"score_gpt":0.2393526777700979,"score_spread":0.2294650038578077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}