{"id":"W2593722226","doi":"10.1182/blood.v126.23.4012.4012","title":"Identification of a New AHI-1-Mediated-PP2A-Beta-Catenin-BCR-ABL-JAK2 Complex Modulating Resistance of CML Stem/Progenitor Cells to Tyrosine Kinase Inhibitors","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Beetle Biology and Toxicology Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Protein phosphatase 2; Cancer research; Imatinib mesylate; Progenitor cell; Stem cell; Tyrosine kinase; Biology; Cell biology; Signal transduction; Imatinib; Phosphatase; Phosphorylation; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072825,0.0004576888,0.0002780307,0.0003413643,0.0002218784,0.0002862574,0.0002978733,0.0002719131,0.001784995],"category_scores_gemma":[0.00008340755,0.0001577557,0.0002658625,0.0001709331,0.0001561849,0.0001217711,0.0001980962,0.0004478605,0.0004349855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000477758,"about_ca_system_score_gemma":0.000267109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281387,"about_ca_topic_score_gemma":0.000679027,"domain_scores_codex":[0.9999284,0.000009288317,0.000004649616,0.00001564465,0.00002501053,0.00001701204],"domain_scores_gemma":[0.9999532,0.000005658645,0.00001033778,0.000003509072,0.000008116208,0.0000191477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006279527,0.00003261988,0.0001173334,0.00003038496,0.000007160023,0.00005014795,0.000004964998,0.00007543815,0.9985313,0.000072538,0.00005162931,0.00096361],"study_design_scores_gemma":[0.00006617606,0.0003839468,0.003410255,0.000004264321,0.00002730609,0.0002801142,0.00001194568,0.001555552,0.9907628,0.00005434578,0.003437188,0.000006188322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905392,0.002063702,0.004078695,0.0001890514,0.00004807305,0.0002228998,0.0006410315,0.0001295754,0.002087845],"genre_scores_gemma":[0.9921792,0.0006648978,0.003247091,0.00008103954,0.00001109099,0.00007191794,0.001101515,0.00001409557,0.002629152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784995,"threshold_uncertainty_score":0.005971372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331472728836247,"score_gpt":0.2618291179025702,"score_spread":0.2286818450189455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}