{"id":"W2593722226","doi":"10.1182/blood.v126.23.4012.4012","title":"Identification of a New AHI-1-Mediated-PP2A-Beta-Catenin-BCR-ABL-JAK2 Complex Modulating Resistance of CML Stem/Progenitor Cells to Tyrosine Kinase Inhibitors","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Beetle Biology and Toxicology Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Protein phosphatase 2; Cancer research; Imatinib mesylate; Progenitor cell; Stem cell; Tyrosine kinase; Biology; Cell biology; Signal transduction; Imatinib; Phosphatase; Phosphorylation; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002924817,0.0001803124,0.0003159152,0.00006240003,0.0000631526,0.00000628039,0.0002170981,0.0002327414,0.000004058109],"category_scores_gemma":[0.0001308419,0.0001731524,0.00009010117,0.0001787646,0.0001699028,0.000005253311,0.0001527227,0.00007438107,0.00001235148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121569,"about_ca_system_score_gemma":0.0001149161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002246583,"about_ca_topic_score_gemma":0.0000774636,"domain_scores_codex":[0.9986236,0.00008928549,0.0005324578,0.0003756219,0.0001413632,0.0002376567],"domain_scores_gemma":[0.99889,0.00002640982,0.0003337679,0.000364186,0.0002461328,0.0001395101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468356,0.0002441076,0.008713401,0.00004174446,0.0001670892,0.000002486172,0.000163526,0.00002039945,0.9847664,0.00003762456,0.005508771,0.0001876595],"study_design_scores_gemma":[0.001221424,0.0003163526,0.006087103,0.0000215197,0.00009708179,0.000002796213,0.0001535723,0.000009772232,0.9884123,0.00003762012,0.003473125,0.0001672839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964687,0.00227814,0.0001672423,0.0002220193,0.0002806841,0.0002969324,0.0001170502,0.00001581842,0.0001534632],"genre_scores_gemma":[0.997282,0.00003609476,0.001287395,0.00007762988,0.0002647544,0.0000248515,0.00008796412,0.0000193211,0.0009199821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645994,"threshold_uncertainty_score":0.7060949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0331472728836247,"score_gpt":0.2618291179025702,"score_spread":0.2286818450189455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}