{"id":"W2593869870","doi":"10.1016/j.jad.2017.03.032","title":"Tolerability of cariprazine in the treatment of acute bipolar I mania: A pooled post hoc analysis of 3 phase II/III studies","year":2017,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Placebo; Tolerability; Bipolar I disorder; Internal medicine; Akathisia; Medicine; Post-hoc analysis; Extrapyramidal symptoms; Population; Antipsychotic; Adverse effect; Mania; Bipolar disorder; Psychiatry; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02207468,0.002308141,0.0062107,0.001333635,0.0003779529,0.001740149,0.0007787662,0.001033642,0.002272496],"category_scores_gemma":[0.01425954,0.0008083235,0.01789783,0.001478317,0.0006989977,0.0008877512,0.0007858561,0.001101163,0.0002653112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009691484,"about_ca_system_score_gemma":0.00136691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007597068,"about_ca_topic_score_gemma":0.001891548,"domain_scores_codex":[0.9881905,0.007912745,0.001589125,0.001022478,0.000942665,0.0003424911],"domain_scores_gemma":[0.9853235,0.00668396,0.005125165,0.00120757,0.001215592,0.0004442359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.5907592,0.0009551688,0.01906627,0.01104451,0.3405426,0.000143297,0.0001381046,0.001754532,0.005872739,0.0000594318,0.001230816,0.0284333],"study_design_scores_gemma":[0.2130205,0.09192102,0.1380569,0.001048048,0.5457162,0.0003405366,0.0001675875,0.002174296,0.002990173,0.0002925006,0.004100339,0.0001718024],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8330423,0.142014,0.006329167,0.0004265682,0.0006937517,0.007858779,0.006458019,0.0003356289,0.002841762],"genre_scores_gemma":[0.974861,0.01475734,0.002279006,0.0006130951,0.0004472009,0.002890185,0.003488954,0.00008935406,0.0005739148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02207468,"threshold_uncertainty_score":0.1167435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902664113471777,"score_gpt":0.3540255506839226,"score_spread":0.3349989095492048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}