{"id":"W2593895879","doi":"10.1093/neuonc/now293.000","title":"PP01. TARGETING MYC/MYCN BY INHIBITION OF CHECKPOINT KINASE 1 (CHK1) SENSITIZES PAEDIATRIC GLIOBLASTOMA (PGBM) CELLS TO TEMOZOLOMIDE","year":2017,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Synthetic lethality; Cancer research; Kinome; Biology; Gene; ATRX; Downregulation and upregulation; Kinase; Temozolomide; Mutation; Genetics; DNA repair; Glioma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001028295,0.0002637506,0.0003174888,0.0001846917,0.0001290403,0.000317752,0.0002458765,0.0002317344,0.002146219],"category_scores_gemma":[0.00009651348,0.0001316791,0.0002031498,0.0002224452,0.0001576589,0.0001227883,0.0001464976,0.0006535938,0.0006241778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266565,"about_ca_system_score_gemma":0.000337154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142932,"about_ca_topic_score_gemma":0.002707782,"domain_scores_codex":[0.9999187,0.000009201455,0.000008671851,0.00001467598,0.000021718,0.00002699578],"domain_scores_gemma":[0.9999545,0.000009019943,0.00001048669,0.000005252227,0.0000047781,0.00001603931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00116916,0.0004152614,0.001150864,0.0001822057,0.00003251436,0.0001437996,0.00004357383,0.0005258728,0.9815903,0.0003088447,0.001174339,0.01326321],"study_design_scores_gemma":[0.0002976276,0.004460488,0.02198266,0.00001799548,0.00005265431,0.0007401566,0.00007708354,0.002188808,0.9603383,0.0001000504,0.009733073,0.00001109837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909677,0.00201596,0.0009101655,0.0002108677,0.00008124127,0.00009661939,0.00131106,0.0002101497,0.004196149],"genre_scores_gemma":[0.9916983,0.00137204,0.0009395985,0.0001020969,0.00001252845,0.00008277859,0.00263845,0.00002259319,0.003131655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002146219,"threshold_uncertainty_score":0.007179797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01302157589540428,"score_gpt":0.2762647833167786,"score_spread":0.2632432074213743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}