{"id":"W2593902424","doi":"10.1038/srep43358","title":"The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; National Institute of Mental Health; National Institutes of Health; University of Texas Southwestern Medical Center; Welch Foundation","keywords":"Channelrhodopsin; Optogenetics; Mutant; Conductance; Biophysics; Chemistry; Halorhodopsin; Ion; Ion channel; Kinetics; Biology; Biochemistry; Gene; Physics; Membrane; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002547976,0.00009487612,0.0001494153,0.0001174914,0.001134462,0.0005479399,0.0001966863,0.00004090819,0.000006108801],"category_scores_gemma":[0.002594715,0.0000717576,0.00004047626,0.0002235459,0.0006852824,0.0002226736,0.0002151162,0.000167834,0.000001931011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000371207,"about_ca_system_score_gemma":0.00006232408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004830722,"about_ca_topic_score_gemma":0.0003505537,"domain_scores_codex":[0.9980894,0.000163774,0.0003216066,0.0005330505,0.0004997354,0.0003924089],"domain_scores_gemma":[0.998502,0.0002035594,0.0003030532,0.000807875,0.0001063734,0.0000771111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007656139,0.00003915559,0.01206081,0.000006868001,0.000001354553,0.0000848138,0.0002926661,0.000002636104,0.9862369,0.0007288448,0.0002795347,0.0002587212],"study_design_scores_gemma":[0.0001489291,0.00002016004,0.1684926,0.0000294668,0.000002647584,0.00006946589,0.00008594433,0.00116805,0.8233628,0.005563788,0.0009578641,0.00009821366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929762,0.0001034772,0.00006313906,0.0001322485,0.004439427,0.0002850567,0.00001425591,0.00001088435,0.001975261],"genre_scores_gemma":[0.9988179,0.00005195685,0.0000954611,0.00001145493,0.00004983246,0.000006241968,0.000003230929,0.000007694485,0.0009562811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1628741,"threshold_uncertainty_score":0.8725479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05190917456706874,"score_gpt":0.3406399090528928,"score_spread":0.2887307344858241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}