{"id":"W2593917425","doi":"10.1186/s13024-017-0165-0","title":"Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments","year":2017,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Vlaamse regering; Medical Research Council; KU Leuven; Fonds Wetenschappelijk Onderzoek","keywords":"Tetraspanin; Cell biology; Amyloid precursor protein; Exosome; Secretion; Microvesicle; CD81; Microvesicles; Alpha secretase; Biology; Protein degradation; Signal transducing adaptor protein; Autophagy; Amyloid beta; Alzheimer's disease; Internal medicine; Peptide; Biochemistry; Signal transduction; Medicine; microRNA; Immunology; Disease; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987062,0.0003727667,0.0002158016,0.0002908261,0.0002553044,0.0002910366,0.0001660345,0.0004395466,0.001045925],"category_scores_gemma":[0.0001217244,0.00008502482,0.0002506562,0.000183361,0.0001836879,0.0003879679,0.0003177853,0.0002958838,0.0005767153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768204,"about_ca_system_score_gemma":0.0002222139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001773113,"about_ca_topic_score_gemma":0.0001450771,"domain_scores_codex":[0.9999117,0.00001418652,0.00001027064,0.00002099497,0.00002661252,0.00001629629],"domain_scores_gemma":[0.9999303,0.000003838724,0.00002420062,0.000004003628,0.00001414442,0.00002344853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003434073,0.00003022861,0.001390014,0.0001873719,0.00001383223,0.000584855,0.00003753862,0.0001289596,0.9873846,0.0005205682,0.0003579117,0.009020674],"study_design_scores_gemma":[0.00003838651,0.0005766934,0.03253006,0.00004648104,0.00004707409,0.007651869,0.00009482458,0.001326308,0.9338493,0.001105682,0.02271723,0.00001599713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672298,0.01954898,0.008421604,0.0004528019,0.000115537,0.00008001702,0.0008968043,0.000223321,0.003031062],"genre_scores_gemma":[0.9795674,0.006853249,0.007849508,0.0001041277,0.00005541817,0.00003976802,0.001302379,0.00002309459,0.004204974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001045925,"threshold_uncertainty_score":0.003498912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01775150107356669,"score_gpt":0.26542628698751,"score_spread":0.2476747859139433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}