{"id":"W2593966541","doi":"10.7554/elife.20922","title":"A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation","year":2017,"lang":"en","type":"article","venue":"eLife","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Leids Universitair Medisch Centrum; KWF Kankerbestrijding; European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Ubiquitin; PALB2; Homologous recombination; DNA repair; Histone; DNA damage; RAD51; Ubiquitin ligase; Chromatin; Cell biology; DNA; Genetics; Biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006673181,0.0001419272,0.0001648509,0.00007357163,0.0001745551,0.0001202797,0.0003089239,0.000156036,0.00003479357],"category_scores_gemma":[0.0008855902,0.0001505017,0.00006186681,0.00004706958,0.00001691178,0.00001738495,0.0002090787,0.00009401519,0.00005969438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005280082,"about_ca_system_score_gemma":0.00004659466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399163,"about_ca_topic_score_gemma":0.0005968467,"domain_scores_codex":[0.9988322,0.00009054116,0.0002911672,0.0003754044,0.0001784136,0.0002322825],"domain_scores_gemma":[0.9989582,0.00002269812,0.0002384975,0.0006205227,0.00008599767,0.00007411164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004265972,0.00005615486,0.001968802,0.000008685256,0.00001240222,0.00000979091,0.0001814047,0.00002087764,0.9882718,0.0001027158,0.0004548477,0.008869899],"study_design_scores_gemma":[0.0006553546,0.0002809409,0.03926409,0.00005551237,0.000004966781,0.00001957036,0.000171451,0.0004465756,0.9572647,0.0002604452,0.001359629,0.0002167529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962792,0.00002141665,0.0007605517,0.0005519696,0.0003896405,0.0003042106,0.000004771039,0.00002413461,0.001664053],"genre_scores_gemma":[0.996465,0.000009081472,0.002743789,0.0002199238,0.0001655859,0.00004815338,0.00006126537,0.00002417656,0.0002630762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03729529,"threshold_uncertainty_score":0.6137282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0171136617870161,"score_gpt":0.2973586119408829,"score_spread":0.2802449501538667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}