{"id":"W2593998160","doi":"10.1158/0008-5472.can-16-2066","title":"<i>Cyp24a1</i> Attenuation Limits Progression of <i>BrafV600E</i> -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"National Institutes of Health; King Abdulaziz City for Science and Technology; Cancer Research UK","keywords":"Papillary thyroid cancer; Cancer; Thyroid cancer; Medicine; Medullary thyroid cancer; Cancer research; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001752899,0.0003943195,0.0003844982,0.0002691582,0.0001630418,0.0003014854,0.000312462,0.0003075803,0.001850231],"category_scores_gemma":[0.0001178191,0.0001803689,0.0004032528,0.0001935392,0.0002838482,0.00017019,0.0001595253,0.0008937275,0.0005337967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003960227,"about_ca_system_score_gemma":0.0003438934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692697,"about_ca_topic_score_gemma":0.0019369,"domain_scores_codex":[0.9997513,0.00003415452,0.00002403607,0.00004218647,0.00007311768,0.00007518136],"domain_scores_gemma":[0.9998857,0.00001504531,0.00002900988,0.00001862881,0.00001479886,0.00003694235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001926869,0.00008439709,0.0001178272,0.00002389163,0.000006277505,0.00001948788,0.000008061584,0.0000540162,0.9984779,0.00006752334,0.0001277705,0.0008201814],"study_design_scores_gemma":[0.00003066564,0.0007641644,0.002141719,0.000002600652,0.0000157734,0.0001469339,0.00002181101,0.0006736303,0.9934628,0.00002591772,0.002710513,0.000003593918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948488,0.0008471088,0.001179894,0.0001659102,0.00005543856,0.00005046534,0.0007626961,0.00019016,0.001899548],"genre_scores_gemma":[0.9931764,0.0005371779,0.0009244827,0.00005372217,0.00001307412,0.00007015846,0.001365553,0.00004270742,0.003816807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001850231,"threshold_uncertainty_score":0.006189585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106293060835745,"score_gpt":0.4237736229790994,"score_spread":0.3131443168955249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}