{"id":"W2594006964","doi":"10.1021/jacs.6b12830","title":"In Situ Reconstitution of the Adenosine A<sub>2A</sub> Receptor in Spontaneously Formed Synthetic Liposomes","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Chemistry; National Institute of General Medical Sciences; Human Frontier Science Program","keywords":"Chemistry; Transmembrane protein; Receptor; Liposome; Adenosine receptor; G protein-coupled receptor; Biophysics; Ligand (biochemistry); In situ; Vesicle; Adenosine; Adenosine A2A receptor; Proximity ligation assay; Cell surface receptor; Membrane; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636039,0.0001115672,0.0002727152,0.00001278974,0.00008754336,0.00001958657,0.0006164098,0.000091239,0.000008239846],"category_scores_gemma":[0.0003481987,0.0000671103,0.0004060918,0.00008798941,0.0004316799,0.00001169492,0.00016892,0.0002810567,5.603144e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008491849,"about_ca_system_score_gemma":0.0001216482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003519678,"about_ca_topic_score_gemma":0.0000217498,"domain_scores_codex":[0.9990597,0.00006119989,0.0003746736,0.0001328258,0.0001911227,0.0001804639],"domain_scores_gemma":[0.9986647,0.00003070728,0.0008579071,0.0003343769,0.00006861211,0.00004371364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009624239,0.00005884883,0.001305913,0.000009705316,0.00003250006,0.000001677068,0.000102953,0.0000259652,0.9961463,0.00001176667,0.0006935304,0.001514588],"study_design_scores_gemma":[0.0003663179,0.00008112157,0.001326572,0.0001216245,0.00001767122,0.00009059154,0.0001828735,0.00001834735,0.9970033,0.0001806565,0.0005253236,0.00008564934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977419,0.0001758759,0.00006190731,0.001596113,0.0002621517,0.00008986216,0.000003829251,9.840785e-7,0.00006738821],"genre_scores_gemma":[0.9985735,0.000414345,0.0005160797,0.0002663788,0.0001921606,0.000002191662,7.554524e-7,0.000009707443,0.00002488771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001428938,"threshold_uncertainty_score":0.2736679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477108553077084,"score_gpt":0.2363071921623077,"score_spread":0.2288300836092306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}