{"id":"W2594006964","doi":"10.1021/jacs.6b12830","title":"In Situ Reconstitution of the Adenosine A<sub>2A</sub> Receptor in Spontaneously Formed Synthetic Liposomes","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Chemistry; National Institute of General Medical Sciences; Human Frontier Science Program","keywords":"Chemistry; Transmembrane protein; Receptor; Liposome; Adenosine receptor; G protein-coupled receptor; Biophysics; Ligand (biochemistry); In situ; Vesicle; Adenosine; Adenosine A2A receptor; Proximity ligation assay; Cell surface receptor; Membrane; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859549,0.0003646765,0.00023758,0.0001020031,0.0001162377,0.0003449464,0.0002835682,0.0002950179,0.0005129586],"category_scores_gemma":[0.0002481239,0.0001883063,0.0002655096,0.00008401855,0.000226761,0.0004496884,0.000330792,0.0005617946,0.000447888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002801065,"about_ca_system_score_gemma":0.0001775048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002193713,"about_ca_topic_score_gemma":0.0002215308,"domain_scores_codex":[0.9998721,0.00002765659,0.00001561682,0.0000388521,0.00002385932,0.00002187826],"domain_scores_gemma":[0.9998894,0.00002792504,0.00003714987,0.0000198463,0.00001379965,0.00001179767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002450992,0.00000640973,0.00003143207,0.00001585968,0.000002973845,0.00002226758,0.00001256994,0.00006970271,0.9992218,0.000233359,0.00001315214,0.0003459401],"study_design_scores_gemma":[0.00000446806,0.00004745535,0.00009351613,0.000001507908,0.000005499708,0.0000514867,0.000007443972,0.0005705086,0.9981397,0.0000315043,0.001044574,0.000002284002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.950281,0.001134964,0.0461446,0.0001957395,0.00007405072,0.0001007523,0.0004682663,0.0002411291,0.001359509],"genre_scores_gemma":[0.9754983,0.0009479062,0.02074104,0.00004815388,0.00001661651,0.00007870873,0.0005910916,0.00007474611,0.002003401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005129586,"threshold_uncertainty_score":0.00203234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007477108553077084,"score_gpt":0.2363071921623077,"score_spread":0.2288300836092306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}