{"id":"W2594032372","doi":"10.1182/blood.v126.23.1568.1568","title":"Whole Exome Sequencing Reveals That DNMT3A and ASXL1 Mutation Are Involved in the Development of Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia Patients without ABL1 Tyrosine Kinase Domain Mutation","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Ponatinib; Dasatinib; Nilotinib; Tyrosine-kinase inhibitor; Medicine; Myeloid leukemia; Mutation; Imatinib; Imatinib mesylate; Exome sequencing; Tyrosine kinase; Resistance mutation; Cancer research; Internal medicine; Biology; Genetics; Cancer; Reverse transcriptase; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373654,0.0001634957,0.0001900998,0.0006129451,0.0002888335,0.0002358379,0.0001384788,0.0002988304,0.001938131],"category_scores_gemma":[0.000452527,0.0001038775,0.0001622166,0.0004171104,0.0001737683,0.0001373121,0.0002358894,0.000163878,0.0001939326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001408431,"about_ca_system_score_gemma":0.00009429368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007895928,"about_ca_topic_score_gemma":0.001327203,"domain_scores_codex":[0.9998657,0.00001297561,0.00001579115,0.00005228346,0.00002802822,0.00002531076],"domain_scores_gemma":[0.9998382,0.00004980306,0.00004606873,0.00001604506,0.00001823699,0.00003153098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009111075,0.00009271696,0.8732044,0.00005680715,0.00008121076,0.007302919,0.0003527833,0.0001783987,0.1067927,0.000105693,0.0002899969,0.01063131],"study_design_scores_gemma":[0.00002847574,0.0002488393,0.974694,0.00000931527,0.00008080425,0.01613,0.000190194,0.0005395596,0.006939261,0.0000654031,0.001067709,0.000006462488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994618,0.00009145399,0.00009306275,0.00000823828,0.000001037704,0.000004968856,0.0001590748,0.000001565531,0.0001787029],"genre_scores_gemma":[0.9993165,0.00005066529,0.0001384179,0.00001294633,0.000002286722,0.000005098245,0.0003089342,0.000001111252,0.000164208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001938131,"threshold_uncertainty_score":0.006483734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896320036997661,"score_gpt":0.2601334489884377,"score_spread":0.2311702486184611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}