{"id":"W2594049437","doi":"10.1158/1538-7445.sabcs16-p4-22-08","title":"Abstract P4-22-08: A single-arm phase 2 study to assess clinical activity, efficacy and safety of enzalutamide with trastuzumab in HER2+ AR+ metastatic or locally advanced breast cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement; Sunnybrook Health Science Centre","funders":"","keywords":"Enzalutamide; Trastuzumab; Medicine; Oncology; Internal medicine; Metastatic breast cancer; Regimen; Cancer; Phases of clinical research; Breast cancer; Clinical endpoint; Prostate cancer; Androgen receptor; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002454766,0.002754241,0.002340009,0.0006319532,0.0005438814,0.001315504,0.001468265,0.001617584,0.008025547],"category_scores_gemma":[0.001100474,0.000865061,0.001069165,0.0004498117,0.001040093,0.001327166,0.0004773781,0.003362879,0.001682715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001430055,"about_ca_system_score_gemma":0.002719319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108713,"about_ca_topic_score_gemma":0.002885767,"domain_scores_codex":[0.9993207,0.000317369,0.00003349521,0.0001180357,0.00008786636,0.0001224923],"domain_scores_gemma":[0.9992811,0.00006427136,0.0001140669,0.00005006113,0.0000506521,0.0004397899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7222563,0.1540179,0.00396931,0.0006883727,0.001104482,0.0004346255,0.0002336564,0.001852115,0.05686945,0.0003020041,0.006142222,0.05212958],"study_design_scores_gemma":[0.5163581,0.472896,0.004597187,0.00001885404,0.0002272465,0.0002452139,0.00002993094,0.0008065291,0.002480091,0.0001558728,0.002160114,0.00002472914],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849944,0.001046269,0.0007925765,0.0006128392,0.0001330043,0.007518057,0.002202423,0.0002312641,0.002469154],"genre_scores_gemma":[0.9717183,0.001171668,0.003490849,0.001298687,0.0002714352,0.009274477,0.004942177,0.00008224307,0.007750287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008025547,"threshold_uncertainty_score":0.02684814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.257187020499096,"score_gpt":0.5508135852009494,"score_spread":0.2936265647018534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}