{"id":"W2594218383","doi":"10.3390/ph10010027","title":"Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks","year":2017,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Computational biology; Phosphorylation; Posttranslational modification; Kinase; Casein kinase 2; Biology; Protein phosphorylation; Computer science; Protein kinase A; Bioinformatics; Cell biology; Biochemistry; Enzyme; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001680947,0.0006532891,0.001109321,0.0001676278,0.0005311196,0.0001516982,0.0007091176,0.0009359819,0.00009982438],"category_scores_gemma":[0.00058764,0.0005894811,0.0006226249,0.0001854322,0.0002768799,0.00001156035,0.0003647505,0.001009547,0.0001514596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007147284,"about_ca_system_score_gemma":0.0003795395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001820521,"about_ca_topic_score_gemma":0.000001235261,"domain_scores_codex":[0.9963366,0.0008769884,0.0009832648,0.000924039,0.0003211002,0.0005579686],"domain_scores_gemma":[0.9971049,0.00005207624,0.0008937775,0.001401091,0.000129849,0.0004183507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008611639,0.0002124187,0.00001399581,0.007604505,0.0006867919,0.0001360689,0.00002065977,0.0002390537,0.004609978,0.002964686,0.003003605,0.9804221],"study_design_scores_gemma":[0.0003543553,0.00003484236,0.000001404342,0.002658135,0.0005577816,0.00002907425,0.000001941367,0.0004903455,0.006280228,0.0001281944,0.9887691,0.0006945565],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006766988,0.9926803,0.004074286,0.00005667094,0.0003006565,0.002001773,0.00004273679,0.00006571149,0.0007102219],"genre_scores_gemma":[0.004500118,0.989271,0.0007374164,0.00009101122,0.001419755,0.0005421177,0.0008427636,0.0001555053,0.002440247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9857655,"threshold_uncertainty_score":0.9996557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1690120058490926,"score_gpt":0.3939247996035041,"score_spread":0.2249127937544115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}