{"id":"W2594218383","doi":"10.3390/ph10010027","title":"Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks","year":2017,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Computational biology; Phosphorylation; Posttranslational modification; Kinase; Casein kinase 2; Biology; Protein phosphorylation; Computer science; Protein kinase A; Bioinformatics; Cell biology; Biochemistry; Enzyme; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007104113,0.0008498438,0.00126474,0.001741634,0.0003286181,0.00145145,0.001154009,0.001149825,0.001527084],"category_scores_gemma":[0.0006402392,0.0003753522,0.0004335094,0.002059493,0.001109236,0.001975985,0.0008304755,0.002069606,0.001164715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001245776,"about_ca_system_score_gemma":0.001242091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008674353,"about_ca_topic_score_gemma":0.001284293,"domain_scores_codex":[0.9997615,0.00004645369,0.00003008058,0.00005457132,0.00007694836,0.00003038551],"domain_scores_gemma":[0.9996769,0.0001646418,0.00005152509,0.000012935,0.00006329637,0.00003069108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008264587,0.00003812997,0.00035873,0.01600968,0.0001432148,0.000479226,0.0001747674,0.001589471,0.004863289,0.030478,0.01637506,0.9294077],"study_design_scores_gemma":[0.00001484153,0.00006067057,0.001107784,0.00224018,0.0001211117,0.001589226,0.00008873143,0.0003974756,0.001497317,0.01239823,0.9804495,0.00003505986],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002387412,0.9973272,0.0006644593,0.0004941105,0.0001514483,0.00000554855,0.00001592772,0.00001174544,0.001090708],"genre_scores_gemma":[0.001870505,0.9967468,0.000478838,0.0001927445,0.0002077476,0.000009270109,0.00002938952,0.000001978877,0.0004626836],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001741634,"threshold_uncertainty_score":0.009038806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1690120058490926,"score_gpt":0.3939247996035041,"score_spread":0.2249127937544115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}