{"id":"W2594226370","doi":"10.1038/ncomms14683","title":"Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Kommission für Technologie und Innovation; European Commission; British Heart Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Mechanism of action; PI3K/AKT/mTOR pathway; Tubulin; Mode of action; Microtubule; Microtubule polymerization; Mechanism (biology); Chemistry; Pharmacology; Computational biology; Biology; Cell biology; Biochemistry; Signal transduction; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002214726,0.0003650792,0.0003901919,0.0001914908,0.0001898973,0.00069704,0.0004768312,0.0004504785,0.001763972],"category_scores_gemma":[0.0002067006,0.0002418428,0.0003487299,0.0001454347,0.0003248983,0.0006860208,0.0003146944,0.0009629324,0.0003872307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008074497,"about_ca_system_score_gemma":0.0005238668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004885209,"about_ca_topic_score_gemma":0.0005515702,"domain_scores_codex":[0.9998902,0.00001106357,0.000006854657,0.00002045127,0.00004692441,0.00002443349],"domain_scores_gemma":[0.9999408,0.000007701336,0.00002337023,0.000007077517,0.000009162403,0.00001196209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005377309,0.00007262538,0.001077974,0.0001657967,0.00003277865,0.0002198292,0.00003600927,0.005402743,0.9511297,0.01189142,0.0004860997,0.02894732],"study_design_scores_gemma":[0.0001507269,0.0006875973,0.00522256,0.00002802649,0.00006421988,0.001604176,0.00007703519,0.04855045,0.922698,0.005164786,0.01571567,0.00003675538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9130255,0.005820256,0.05997336,0.00141374,0.00006515148,0.000129125,0.0006009399,0.0005674548,0.01840434],"genre_scores_gemma":[0.9816599,0.002889219,0.01305101,0.0002075341,0.00001145168,0.00005169541,0.000368124,0.000040398,0.001720624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763972,"threshold_uncertainty_score":0.005901039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03038627562718204,"score_gpt":0.3259253606941382,"score_spread":0.2955390850669562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}