{"id":"W2594319486","doi":"10.1182/blood.v128.22.347.347","title":"Results of a Phase II Study of Guadecitabine (SGI-110) in Higher Risk MDS, CMML or Low Blast Count AML Patients Refractory to or Relapsing after Azacitidine (AZA) Treatment","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Decitabine; Azacitidine; Internal medicine; Medicine; Gastroenterology; Hypomethylating agent; International Prognostic Scoring System; Myelodysplastic syndromes; Phases of clinical research; Refractory (planetary science); Neutropenia; Bone marrow; Oncology; Clinical trial; DNA methylation; Toxicity; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002824247,0.001336256,0.002307031,0.0003748757,0.0005249237,0.0008974531,0.0008660908,0.001188643,0.003578003],"category_scores_gemma":[0.001295273,0.0006867072,0.001412775,0.0004661775,0.001239821,0.0007172201,0.0003979996,0.003039268,0.001001129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00104097,"about_ca_system_score_gemma":0.002165934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195396,"about_ca_topic_score_gemma":0.002723402,"domain_scores_codex":[0.9990707,0.000473399,0.0000733027,0.0001810826,0.00007356069,0.0001280104],"domain_scores_gemma":[0.9987368,0.0002030327,0.0001403928,0.0001367691,0.00009020475,0.0006927903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.631846,0.1783327,0.01412037,0.001171371,0.002537527,0.0006085394,0.0005946336,0.002589709,0.09422352,0.0002593325,0.00415953,0.06955686],"study_design_scores_gemma":[0.3405958,0.6275796,0.02015207,0.00003835,0.001269379,0.0004016223,0.00008480273,0.0006256782,0.005784749,0.0001926606,0.003234544,0.00004077309],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912486,0.001561422,0.0007250863,0.0003451243,0.0001124228,0.00331722,0.001497107,0.00005178662,0.001141261],"genre_scores_gemma":[0.9856489,0.001475424,0.002326143,0.0008916767,0.0001847087,0.003147891,0.004029766,0.00003769241,0.002257854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003578003,"threshold_uncertainty_score":0.01493621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0302309858913112,"score_gpt":0.3139185120202272,"score_spread":0.2836875261289161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}