{"id":"W2594377120","doi":"10.1038/ncomms14378","title":"A microRNA-initiated DNAzyme motor operating in living cells","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":572,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Deoxyribozyme; microRNA; Cell biology; Biology; Computational biology; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950447,0.0002716452,0.0002146905,0.0001312919,0.0001702639,0.0002768795,0.0003720346,0.0006632768,0.0006051675],"category_scores_gemma":[0.0002470941,0.0001884211,0.0002105273,0.00008576094,0.0002817669,0.0003341601,0.0002045465,0.0003421142,0.0005680245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002560924,"about_ca_system_score_gemma":0.0002239448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001910941,"about_ca_topic_score_gemma":0.0002513478,"domain_scores_codex":[0.9998411,0.00002142638,0.00001107216,0.00005724741,0.00005370332,0.00001533048],"domain_scores_gemma":[0.9999136,0.0000170222,0.00001966784,0.000009877264,0.00001816809,0.00002169521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001833371,0.00001025818,0.00007363106,0.00002603458,0.000002613345,0.00005077504,0.000009124863,0.0001162737,0.9971353,0.0005210453,0.00005903189,0.001977541],"study_design_scores_gemma":[0.000008953339,0.0001195338,0.0002347514,0.000002219406,0.00000420198,0.0001851817,0.000003676504,0.002444004,0.9924996,0.0000855796,0.004406093,0.000006130888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8224804,0.002871695,0.161942,0.0007732977,0.0004799532,0.000220862,0.0002370593,0.00141933,0.009575467],"genre_scores_gemma":[0.8536419,0.0009587446,0.1299534,0.0001973966,0.00004356368,0.0001476285,0.0002839844,0.00008011195,0.01469345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006632768,"threshold_uncertainty_score":0.002024472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02317625316144176,"score_gpt":0.3359491537315417,"score_spread":0.3127729005700999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}