{"id":"W2594407313","doi":"10.1158/2326-6074.tumimm16-pr09","title":"Abstract PR09: A novel chimeric antigen receptor containing JAK-STAT signaling domains mediates superior antitumor effects","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chimeric antigen receptor; Cancer research; CD19; Cytokine; CD28; STAT5; T cell; T-cell receptor; JAK-STAT signaling pathway; Cytokine receptor; Signal transduction; Immunology; Biology; Medicine; Tyrosine kinase; Cell biology; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002691195,0.0003873707,0.0009411599,0.0006378522,0.001633645,0.0003107376,0.001189417,0.0003817645,0.00583867],"category_scores_gemma":[0.002240401,0.0003446936,0.0002229767,0.0004426568,0.002414921,0.0003364258,0.0006129514,0.002260442,0.000427389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006540205,"about_ca_system_score_gemma":0.001597994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002519575,"about_ca_topic_score_gemma":0.0001264511,"domain_scores_codex":[0.9951888,0.0003084098,0.0005103927,0.0009238739,0.001131991,0.001936475],"domain_scores_gemma":[0.9957231,0.001248742,0.0002001825,0.001617642,0.0008236581,0.0003866496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002750212,0.0002275229,0.06103952,0.0002692279,0.0007247382,0.0003151302,0.001054104,0.000002097687,0.9105674,0.00006856083,0.0004629064,0.02251855],"study_design_scores_gemma":[0.008689327,0.00184236,0.377007,0.00100173,0.00005095037,0.0001185302,0.001154959,0.00007158225,0.5836062,0.00005625326,0.02590808,0.0004930302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822592,0.009577832,0.00002393453,0.002465592,0.0008572078,0.00178449,0.00004757858,0.0001120969,0.00287203],"genre_scores_gemma":[0.988214,0.006160513,0.0003713171,0.0001174142,0.0008595166,0.0005857708,0.00005306376,0.0001365117,0.003501893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3269612,"threshold_uncertainty_score":0.9999005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08268631610408858,"score_gpt":0.4196002134770678,"score_spread":0.3369138973729792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}