{"id":"W2594407313","doi":"10.1158/2326-6074.tumimm16-pr09","title":"Abstract PR09: A novel chimeric antigen receptor containing JAK-STAT signaling domains mediates superior antitumor effects","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chimeric antigen receptor; Cancer research; CD19; Cytokine; CD28; STAT5; T cell; T-cell receptor; JAK-STAT signaling pathway; Cytokine receptor; Signal transduction; Immunology; Biology; Medicine; Tyrosine kinase; Cell biology; Antigen; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444085,0.0003606242,0.0002060526,0.0001494412,0.00008928376,0.0002901982,0.000283588,0.0003321853,0.001882942],"category_scores_gemma":[0.00007187959,0.0001188995,0.0002486909,0.0001090909,0.0002068122,0.0002261804,0.0001733465,0.0006595926,0.0007596449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000272841,"about_ca_system_score_gemma":0.0002041128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002710856,"about_ca_topic_score_gemma":0.0002398912,"domain_scores_codex":[0.9998839,0.00001870713,0.00001055453,0.00002223088,0.00003308985,0.00003138985],"domain_scores_gemma":[0.9999499,0.000007073114,0.00001318085,0.000005944628,0.000006346131,0.00001754619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001524996,0.00006134335,0.00006616939,0.00002337812,0.000003825694,0.00002663268,0.000004234366,0.0001423802,0.998054,0.0001528652,0.00008697595,0.001225672],"study_design_scores_gemma":[0.0001710553,0.001269431,0.001068608,0.000003695978,0.00002798641,0.0004246904,0.000007254469,0.002327429,0.9906107,0.00003612308,0.004048393,0.000004563231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904794,0.001275728,0.005304592,0.0001946412,0.00004865423,0.00005447046,0.0003755366,0.0002236951,0.002043308],"genre_scores_gemma":[0.9949915,0.0003305006,0.002258842,0.00004181261,0.000009305838,0.00002279882,0.000559878,0.00001901765,0.001766506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001882942,"threshold_uncertainty_score":0.006299078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08268631610408858,"score_gpt":0.4196002134770678,"score_spread":0.3369138973729792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}