{"id":"W2594441236","doi":"10.1161/circulationaha.116.025233","title":"Pooled Safety Analysis of Evolocumab in Over 6000 Patients From Double-Blind and Open-Label Extension Studies","year":2017,"lang":"en","type":"review","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Amgen","keywords":"Medicine; Evolocumab; Open label; Extension (predicate logic); Double blind; Clinical trial; Internal medicine; Placebo; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04414677,0.002143376,0.006559981,0.002451077,0.0004896727,0.001683249,0.000721537,0.001406727,0.00278652],"category_scores_gemma":[0.04227832,0.001075391,0.01376075,0.001818826,0.0005792031,0.001321066,0.001258437,0.001320524,0.0004069942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008277549,"about_ca_system_score_gemma":0.001034443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004413375,"about_ca_topic_score_gemma":0.0006156593,"domain_scores_codex":[0.9719339,0.0148777,0.005799646,0.003152552,0.003682096,0.0005540323],"domain_scores_gemma":[0.958566,0.01898134,0.01281076,0.004571143,0.004295561,0.000775287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.4478267,0.0009979897,0.1211481,0.01065563,0.3125346,0.0003539913,0.0004840975,0.004876276,0.007793137,0.0002359423,0.003359739,0.08973385],"study_design_scores_gemma":[0.1302078,0.06900115,0.4385145,0.001428361,0.3334171,0.001626607,0.0002242375,0.006284125,0.004511207,0.001038141,0.01344712,0.0002998094],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8591676,0.101723,0.01611472,0.0002943077,0.0004394088,0.006029016,0.01207006,0.0004000615,0.00376178],"genre_scores_gemma":[0.974399,0.00739323,0.004095321,0.0004259564,0.0003852705,0.003071091,0.00950083,0.00007347485,0.0006558524],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04414677,"threshold_uncertainty_score":0.2334732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2327999701645792,"score_gpt":0.4471507298440213,"score_spread":0.2143507596794421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}