{"id":"W2594451640","doi":"10.3390/molecules22030383","title":"In Vitro Selection of DNA Aptamers that Binds Geniposide","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aptamer; Genipin; Gardenia jasminoides; Gardenia; Chemistry; Systematic evolution of ligands by exponential enrichment; In vitro; DNA; Computational biology; Biochemistry; Molecular biology; Biology; Traditional Chinese medicine; RNA; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009274272,0.0001062239,0.0001377578,0.00006529863,0.00008328007,0.00002042147,0.000173381,0.0001117191,0.00000135527],"category_scores_gemma":[0.00005674498,0.00009705359,0.00008867143,0.00004276727,0.0001227156,0.000005505238,0.0000750934,0.00005635752,8.937178e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001076754,"about_ca_system_score_gemma":0.00001953157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006451327,"about_ca_topic_score_gemma":0.00007841233,"domain_scores_codex":[0.9993761,0.00002734407,0.0001299953,0.000229929,0.00008858057,0.0001480299],"domain_scores_gemma":[0.9994301,0.000003150818,0.0001511547,0.0003435177,0.00004380471,0.00002829524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008381608,0.00002805715,0.001371018,0.000005342257,0.00002447481,0.000003533783,0.000005319032,0.000002191238,0.9948294,0.000012702,0.000181607,0.003452505],"study_design_scores_gemma":[0.0001636699,0.00008015589,0.002859656,0.000009240458,0.00001508926,0.000006686061,0.00001555956,0.00008155056,0.9950777,0.00008712913,0.001488866,0.0001146542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974937,0.00007458002,0.001188541,0.000184962,0.00003658085,0.00006453918,0.000008019002,0.00001200022,0.0009370534],"genre_scores_gemma":[0.9943033,0.0001162052,0.005106104,0.0001064484,0.00004678311,0.00000447814,0.00002375963,0.00001207823,0.0002807871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003917563,"threshold_uncertainty_score":0.3957731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127843604527787,"score_gpt":0.2762097628881653,"score_spread":0.2649313268428874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}