{"id":"W2594495130","doi":"10.1038/ncomms14638","title":"The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute; McGill University; HEC Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Kinome; Cancer research; Immune system; Tyrosine kinase; Breast cancer; Biology; Immune checkpoint; Tumor microenvironment; Immunotherapy; Signal transduction; Immunology; Medicine; Cancer; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001704165,0.0002233107,0.0001950739,0.0001892648,0.0001797812,0.0004100556,0.0001951679,0.0002529327,0.001703263],"category_scores_gemma":[0.0001009336,0.0001253274,0.0001174131,0.0001561306,0.0002161682,0.0002621808,0.0003399721,0.0005381646,0.0004093032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004134256,"about_ca_system_score_gemma":0.0004199949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003817877,"about_ca_topic_score_gemma":0.0008085804,"domain_scores_codex":[0.9998583,0.00001574179,0.000009328412,0.00001944152,0.00003916718,0.00005807511],"domain_scores_gemma":[0.9999043,0.00001511998,0.00002554386,0.00001043557,0.000009778817,0.00003487491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002156341,0.00003187979,0.0002821075,0.00003175666,0.000005200804,0.00003323818,0.00001005803,0.0002419148,0.9961587,0.0002846541,0.0001557085,0.002549133],"study_design_scores_gemma":[0.00003437043,0.0001734224,0.002297566,0.00000469451,0.00001201705,0.0001511617,0.00002062464,0.001794878,0.9918448,0.00009891242,0.003563288,0.000004178527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946189,0.001381849,0.001288594,0.0002226384,0.000036159,0.00001667551,0.0002224775,0.0001258422,0.002086877],"genre_scores_gemma":[0.9977857,0.0003667783,0.000508875,0.00004206633,0.000007886748,0.0000115666,0.0001521163,0.00001292509,0.001112158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001703263,"threshold_uncertainty_score":0.005697966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02400571127142541,"score_gpt":0.3635002283070828,"score_spread":0.3394945170356574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}