{"id":"W2594520312","doi":"10.1016/j.pharep.2017.02.006","title":"Nrf2 and NF-κB modulation by Plumbagin attenuates functional, behavioural and biochemical deficits in rat model of neuropathic pain","year":2017,"lang":"en","type":"article","venue":"Pharmacological Reports","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"Neuropathic pain; Plumbagin; Sciatic nerve; Pharmacology; Medicine; Neuroprotection; Nerve injury; Hyperalgesia; Sciatic nerve injury; Anesthesia; Internal medicine; Nociception; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139067,0.0007076488,0.0007624788,0.0005399059,0.0003188818,0.0002477879,0.0004190547,0.0005367949,0.002758874],"category_scores_gemma":[0.0001817107,0.0002249845,0.0004636991,0.000309605,0.0007496497,0.0006594996,0.0002609964,0.001636005,0.0003157844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521995,"about_ca_system_score_gemma":0.0007021283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010851,"about_ca_topic_score_gemma":0.002178046,"domain_scores_codex":[0.9998776,0.00002262141,0.00001014128,0.00001787529,0.00002678117,0.00004498032],"domain_scores_gemma":[0.9998733,0.000009489182,0.00003211674,0.00001499155,0.00001591083,0.00005424894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005830463,0.0009872768,0.0001721464,0.0003361979,0.00004741786,0.0001937628,0.0000729933,0.0001953706,0.9867513,0.0002599827,0.0001755379,0.004977533],"study_design_scores_gemma":[0.000746283,0.007633449,0.006076373,0.00006423326,0.0001731758,0.0004945411,0.000259569,0.0013983,0.9796889,0.0004944194,0.002938464,0.00003231311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929994,0.003048462,0.001637442,0.0003736196,0.0000855428,0.00005747663,0.0003115347,0.0001551982,0.001331263],"genre_scores_gemma":[0.9904243,0.00319009,0.001623678,0.0001072686,0.00002842867,0.0001487841,0.0004186832,0.00002284722,0.004035889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002758874,"threshold_uncertainty_score":0.009229302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07083824493066634,"score_gpt":0.3197475380052578,"score_spread":0.2489092930745914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}