{"id":"W2594628337","doi":"10.1158/2326-6074.tumimm16-a28","title":"Abstract A28: Adenoviruses up-regulate IL17F, but not IL17A, and activate NK cells, with potential impact on oncolytic adenovirus efficacy","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Oncolytic virus; Oncolytic adenovirus; Chemokine; Biology; Cytokine; Adenoviridae; Immune system; Immunology; Cancer research; Genetic enhancement; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285688,0.000377903,0.0002776299,0.0002700991,0.0001097027,0.0004309562,0.0001315889,0.000242607,0.00518057],"category_scores_gemma":[0.0002139465,0.0001027006,0.0003011028,0.0001682425,0.0002742975,0.0002288062,0.0001755851,0.0005550314,0.0008572772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817354,"about_ca_system_score_gemma":0.000251624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005027818,"about_ca_topic_score_gemma":0.0003999673,"domain_scores_codex":[0.9997483,0.00003389009,0.00003289699,0.00004599137,0.00006216724,0.00007674799],"domain_scores_gemma":[0.9997557,0.00006190798,0.0000566255,0.00002933302,0.00004876166,0.0000477183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002679553,0.00003751853,0.000305775,0.0000452938,0.000004809714,0.00001209679,0.000006955031,0.00004400715,0.9980013,0.00003547074,0.00006810437,0.001170804],"study_design_scores_gemma":[0.00003212134,0.0006048917,0.004416778,0.000008667665,0.00001196065,0.000118913,0.00003029207,0.0002976432,0.9922997,0.00003100152,0.002144768,0.00000324973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9937007,0.001422342,0.001750728,0.00009230545,0.00006158598,0.00004281318,0.001441499,0.00008387164,0.001404116],"genre_scores_gemma":[0.9919568,0.0005155824,0.002340874,0.00006575299,0.00001685282,0.00007227458,0.001225132,0.00003887293,0.003767787],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.00518057,"threshold_uncertainty_score":0.01733071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05472093910081956,"score_gpt":0.3954685184054156,"score_spread":0.3407475793045961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}