{"id":"W2594628337","doi":"10.1158/2326-6074.tumimm16-a28","title":"Abstract A28: Adenoviruses up-regulate IL17F, but not IL17A, and activate NK cells, with potential impact on oncolytic adenovirus efficacy","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Oncolytic virus; Oncolytic adenovirus; Chemokine; Biology; Cytokine; Adenoviridae; Immune system; Immunology; Cancer research; Genetic enhancement; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001026047,0.0004771315,0.0004812238,0.0003207278,0.001345344,0.0003465513,0.001458732,0.0005241351,0.0003905351],"category_scores_gemma":[0.000200526,0.0003775759,0.0001565076,0.0001661173,0.002231366,0.00003562508,0.0007112732,0.001323439,0.0001623806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002518645,"about_ca_system_score_gemma":0.001190029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001360263,"about_ca_topic_score_gemma":0.0003920463,"domain_scores_codex":[0.9959378,0.0003811261,0.0003250415,0.001127592,0.0007506547,0.001477829],"domain_scores_gemma":[0.9968467,0.0001432542,0.0002185387,0.002019585,0.0004629978,0.0003088748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03807358,0.0002021913,0.0007412951,0.00003856038,0.0007290648,0.00009375653,0.00007547343,0.0002642382,0.9275237,0.000008158047,0.0009186465,0.03133135],"study_design_scores_gemma":[0.004146244,0.00690803,0.07478765,0.00009608648,0.00002746703,0.00004011834,0.00008936949,0.00003059257,0.9109356,0.00002583253,0.002469472,0.0004434692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935301,0.003767959,0.000006902117,0.0007611556,0.000312129,0.0007877819,0.0001629799,0.00002999732,0.0006409765],"genre_scores_gemma":[0.9904968,0.005264704,0.0000180593,0.0001290522,0.0005099187,0.0001764285,0.0000402068,0.000120738,0.003244137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07404636,"threshold_uncertainty_score":0.9999548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05472093910081956,"score_gpt":0.3954685184054156,"score_spread":0.3407475793045961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}