{"id":"W2594630594","doi":"10.1038/srep43270","title":"Robust Identification of Alzheimer’s Disease subtypes based on cortical atrophy patterns","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Parkwood Institute; Sunnybrook Health Science Centre; McGill University; Jewish General Hospital","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Ministry of Science ICT and Future Planning; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; National Institutes of Health; Ministry of Science, ICT and Future Planning; National Research Foundation; Northern California Institute for Research and Education; F. Hoffmann-La Roche; Institute for Information and Communications Technology Promotion; Pfizer; BioClinica; Biogen; University of California, San Diego; Takeda Pharmaceuticals U.S.A.; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Subtyping; Atrophy; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Pathology; Neuroscience; Disease; Alzheimer's disease; Medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001458161,0.0008759333,0.000920375,0.005616312,0.0004161225,0.001011658,0.0006996138,0.0006423689,0.0006971699],"category_scores_gemma":[0.004562961,0.0002487843,0.001029696,0.001616172,0.0004261607,0.0007737052,0.0009825756,0.0004851947,0.000504682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000284227,"about_ca_system_score_gemma":0.0005423736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003740625,"about_ca_topic_score_gemma":0.007607785,"domain_scores_codex":[0.9990773,0.0001933043,0.0001082686,0.0003449417,0.0001695697,0.000106607],"domain_scores_gemma":[0.9985842,0.0003537729,0.0003204034,0.0002851565,0.0003579803,0.00009857047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.001328198,0.0003303263,0.3585043,0.0004078709,0.001406094,0.0008383067,0.0006825044,0.02224031,0.08263921,0.00215079,0.008212757,0.5212594],"study_design_scores_gemma":[0.0001368618,0.0003190984,0.5630342,0.00008291138,0.000597429,0.002220605,0.0004507291,0.3987952,0.01815426,0.01247233,0.00361876,0.0001177009],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7963706,0.001266175,0.1959524,0.0002341824,0.00005390712,0.0002849427,0.002571699,0.001637579,0.001628501],"genre_scores_gemma":[0.9107815,0.0003005488,0.0836688,0.00006006307,0.0000780945,0.0001286482,0.004254264,0.0001465965,0.0005816664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005616312,"threshold_uncertainty_score":0.007711649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07595650517673093,"score_gpt":0.2930920705583762,"score_spread":0.2171355653816453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}