{"id":"W2594697025","doi":"10.1158/2326-6074.tumimm16-a74","title":"Abstract A74: CAR-T cells harboring camelid single domain antibody as targeting agent to CEACAM6 antigen in pancreatic cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Helix Biopharma (Canada)","funders":"","keywords":"Antigen; Antibody; Cancer research; Cytotoxic T cell; Biology; CD28; Chimeric antigen receptor; T cell; Pancreatic cancer; Molecular biology; Immunology; Cancer; Immune system; In vitro; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260284,0.0002849648,0.0003797841,0.0002718043,0.0001691225,0.000346262,0.000238561,0.0005902951,0.002486619],"category_scores_gemma":[0.00008893332,0.0001321901,0.0004360604,0.0002386384,0.000133717,0.000203064,0.0001827476,0.0006461503,0.0009716603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003573315,"about_ca_system_score_gemma":0.0001561517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006788604,"about_ca_topic_score_gemma":0.0002460737,"domain_scores_codex":[0.9998242,0.00002377129,0.00001389556,0.00005375278,0.00003061474,0.00005368377],"domain_scores_gemma":[0.9999472,0.00000952689,0.000008237063,0.000007679274,0.00001032235,0.00001695908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001982106,0.00009142647,0.0001788537,0.00003873179,0.000006423702,0.0001192867,0.00001514895,0.0001418456,0.997652,0.000102927,0.0002091642,0.001245997],"study_design_scores_gemma":[0.00006465149,0.001131256,0.002051373,0.000004976856,0.00002933503,0.0007235454,0.00001596117,0.001738623,0.9898262,0.00003622379,0.004371105,0.000006617156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904868,0.001336367,0.003609666,0.0001414783,0.00008450922,0.00009522765,0.0006416673,0.0002358013,0.003368496],"genre_scores_gemma":[0.9936484,0.000428735,0.001921479,0.00009794856,0.00002659524,0.00006730192,0.0007269165,0.00002369654,0.003058948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002486619,"threshold_uncertainty_score":0.008318543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0871099523506898,"score_gpt":0.4419777008787142,"score_spread":0.3548677485280244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}