{"id":"W2594697025","doi":"10.1158/2326-6074.tumimm16-a74","title":"Abstract A74: CAR-T cells harboring camelid single domain antibody as targeting agent to CEACAM6 antigen in pancreatic cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Helix Biopharma (Canada)","funders":"","keywords":"Antigen; Antibody; Cancer research; Cytotoxic T cell; Biology; CD28; Chimeric antigen receptor; T cell; Pancreatic cancer; Molecular biology; Immunology; Cancer; Immune system; In vitro; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002955316,0.000386845,0.0008982692,0.0008967265,0.0008889546,0.0002602866,0.001224664,0.0003875133,0.007778044],"category_scores_gemma":[0.0007689151,0.000374004,0.0001694502,0.000624599,0.0008770223,0.0002393386,0.0008130729,0.002185768,0.0005309794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002182466,"about_ca_system_score_gemma":0.001459618,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03852076,"about_ca_topic_score_gemma":0.001497127,"domain_scores_codex":[0.9944466,0.0004120855,0.0006500999,0.001070292,0.001172458,0.002248515],"domain_scores_gemma":[0.9965926,0.0003707907,0.0001775422,0.001750467,0.000666199,0.0004424156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001352687,0.0002205942,0.1073989,0.0001658452,0.0002875926,0.0007347991,0.001610853,0.00002560801,0.8720008,0.00002525129,0.001092073,0.01508499],"study_design_scores_gemma":[0.002977739,0.0006314598,0.4143162,0.001021049,0.00002414352,0.00002451219,0.001453289,0.00002650337,0.5222064,0.00009070039,0.05679513,0.0004328045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727054,0.009814563,0.000006666883,0.004255661,0.0008124303,0.001816524,0.00003554518,0.00006198436,0.01049122],"genre_scores_gemma":[0.9803113,0.009920112,0.0001891911,0.0001809128,0.000699361,0.0006651366,0.00002406856,0.0001301786,0.007879744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3497944,"threshold_uncertainty_score":0.9998712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0871099523506898,"score_gpt":0.4419777008787142,"score_spread":0.3548677485280244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}