{"id":"W2594850837","doi":"10.1002/open.201600157","title":"Tetrahydropyranyl: A Non‐aromatic, Mild‐Acid‐Labile Group for Hydroxyl Protection in Solid‐Phase Peptide Synthesis","year":2017,"lang":"en","type":"article","venue":"ChemistryOpen","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Population and Public Health; Departament d'Universitats, Recerca i Societat de la Informació; Ministerio de Economía y Competitividad; Inyuvesi Yakwazulu-Natali; Generalitat de Catalunya; King Saud University","keywords":"Chemistry; Trifluoroacetic acid; Protecting group; Peptide synthesis; Tripeptide; Peptide; Moiety; Side chain; Solubility; Serine; Organic chemistry; Combinatorial chemistry; Medicinal chemistry; Alkyl; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003715222,0.000276247,0.0004087526,0.00003165728,0.0002896031,0.0001560094,0.0006888229,0.0002720081,0.00009228757],"category_scores_gemma":[0.001057081,0.0002639094,0.000300898,0.00005887231,0.0001348445,0.00001592406,0.0001910351,0.0001202884,0.00001575878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000498418,"about_ca_system_score_gemma":0.00004274189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001395891,"about_ca_topic_score_gemma":0.00007856621,"domain_scores_codex":[0.9983937,0.00002126865,0.0003905636,0.0006393961,0.0001531001,0.0004019788],"domain_scores_gemma":[0.9985104,0.00003222634,0.0002662744,0.001001251,0.0000464303,0.0001434466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001444726,0.0002814671,0.0003312546,0.0001200933,0.00008594205,0.000003052685,0.00001872049,0.00000497521,0.991789,9.185697e-7,0.000689878,0.006530256],"study_design_scores_gemma":[0.001299844,0.00007618016,0.0003509701,0.0001146481,0.00007212405,0.000005648266,0.00004308106,0.001149054,0.9904009,0.0001362419,0.005992345,0.0003589826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950299,0.0001083211,0.001307123,0.0003016873,0.00004209121,0.0005383083,0.00005743052,0.00001599196,0.002599159],"genre_scores_gemma":[0.9970303,0.00004767898,0.000704063,0.00004185194,0.0003317672,0.0007804277,0.0001046086,0.00004417957,0.0009151256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006171273,"threshold_uncertainty_score":0.9999813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741869849843123,"score_gpt":0.3008237406893293,"score_spread":0.2834050421908981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}