{"id":"W2594862203","doi":"10.1172/jci87442","title":"Laminar flow downregulates Notch activity to promote lymphatic sprouting","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; China Scholarship Council; American Heart Association","keywords":"KLF2; Lymphatic Endothelium; Cell biology; Lymphatic system; ORAI1; Sprouting angiogenesis; Chemistry; Biology; Immunology; Downregulation and upregulation; Cancer research; Angiogenesis; Biochemistry; Neovascularization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600404,0.0004017776,0.0002593426,0.0002988344,0.0001431622,0.0004063914,0.0001867635,0.0002765302,0.001878796],"category_scores_gemma":[0.00009301731,0.000184102,0.0004090981,0.0001370127,0.0002603135,0.0002826341,0.0003466258,0.0007863423,0.0003693883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866387,"about_ca_system_score_gemma":0.0003389757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006111143,"about_ca_topic_score_gemma":0.0007552541,"domain_scores_codex":[0.9998234,0.00001892956,0.00002236554,0.00004188643,0.00004021584,0.00005327952],"domain_scores_gemma":[0.9999039,0.0000104884,0.0000338339,0.000007475764,0.000009592783,0.00003466695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284662,0.00003133007,0.0001460153,0.00005021852,0.000004239813,0.00003206955,0.000009976707,0.000042593,0.9985833,0.0001171216,0.00003357442,0.0008211356],"study_design_scores_gemma":[0.00004930028,0.0002722429,0.005030341,0.00001072682,0.00002659368,0.0001065156,0.00002919176,0.001109268,0.9911708,0.00008276013,0.002105066,0.000007250477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913754,0.001901488,0.00398376,0.0001645619,0.00007086634,0.00004899909,0.000573599,0.0001629975,0.001718399],"genre_scores_gemma":[0.9929863,0.00124794,0.001855695,0.0001282582,0.00002008639,0.00006426448,0.0004814909,0.00002726052,0.003188787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878796,"threshold_uncertainty_score":0.006285191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137929210003285,"score_gpt":0.4215545683787106,"score_spread":0.3077616473783821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}