{"id":"W2594862203","doi":"10.1172/jci87442","title":"Laminar flow downregulates Notch activity to promote lymphatic sprouting","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; China Scholarship Council; American Heart Association","keywords":"KLF2; Lymphatic Endothelium; Cell biology; Lymphatic system; ORAI1; Sprouting angiogenesis; Chemistry; Biology; Immunology; Downregulation and upregulation; Cancer research; Angiogenesis; Biochemistry; Neovascularization","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002521324,0.0001291193,0.0006301827,0.00008073822,0.0001898932,0.0001215502,0.000203444,0.000126906,0.00003057129],"category_scores_gemma":[0.01432875,0.00009245882,0.0002769904,0.00006746459,0.0001620922,0.0004303484,0.00005605235,0.00006329061,0.00004967577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006764295,"about_ca_system_score_gemma":0.0005359486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001844513,"about_ca_topic_score_gemma":0.000003699438,"domain_scores_codex":[0.997835,0.0001646643,0.001143562,0.000177146,0.0005078185,0.0001717852],"domain_scores_gemma":[0.9966029,0.0003390513,0.001541745,0.0004404179,0.0004316788,0.0006441998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009197883,0.0005324218,0.7690629,0.000393931,0.0002474003,0.000188993,0.0005287509,0.00006025166,0.02015021,0.0001009328,0.002429608,0.2053848],"study_design_scores_gemma":[0.002693681,0.0007950143,0.979126,0.001467633,0.0003045085,0.0001392847,0.00005069091,0.003314433,0.01023587,0.001373318,0.0003812874,0.0001182603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903538,0.00005536981,0.0004640483,0.00748179,0.0007328269,0.0002989992,0.000001929785,0.00001608866,0.0005952115],"genre_scores_gemma":[0.9871308,0.0000103647,0.01025609,0.0006795937,0.00157152,0.000003182635,0.000001590077,0.00001471864,0.0003321492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2100631,"threshold_uncertainty_score":0.993974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1137929210003285,"score_gpt":0.4215545683787106,"score_spread":0.3077616473783821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}