{"id":"W2594884273","doi":"10.1139/cjc-2016-0649","title":"Synthesis and biological evaluation of structurally simplified noscapine analogues as microtubule binding agents","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Cyclization and Aryne Chemistry","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Noscapine; Chemistry; Microtubule; Docking (animal); Cytotoxicity; Stereochemistry; Tubulin; Colchicine; Binding site; Combinatorial chemistry; Biophysics; Biochemistry; Alkaloid; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003241758,0.0001581395,0.0002877546,0.00004356596,0.0002450945,0.0001095149,0.0004512521,0.0001932476,0.003965123],"category_scores_gemma":[0.001998892,0.0001459178,0.0001044191,0.00003547172,0.0002621201,0.0001197203,0.00003590218,0.0001965753,0.000002340314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126733,"about_ca_system_score_gemma":0.0006662737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000249588,"about_ca_topic_score_gemma":0.0001358105,"domain_scores_codex":[0.9989155,0.00001394238,0.0004253805,0.0001725082,0.0002549223,0.0002177239],"domain_scores_gemma":[0.998067,0.00005744175,0.0007214774,0.0003228927,0.0003673095,0.0004638426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001661138,0.000009228358,0.02498047,0.0001337253,0.00007764084,0.00003433571,0.00009223659,0.000007909956,0.9708416,0.000003809334,0.0004775511,0.00332488],"study_design_scores_gemma":[0.0005885394,0.000006139304,0.006548993,0.0002360132,0.0000777946,0.0002318083,0.0003634544,0.00006635269,0.9907022,0.0002030734,0.0008169397,0.0001587515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871586,0.0003809302,0.000001602492,0.0002109516,0.0000585791,0.00002518418,0.00008373595,0.000004373922,0.01207603],"genre_scores_gemma":[0.9993748,0.00007559084,0.00006061683,0.00002279062,0.0001703934,0.000001769798,0.00003042832,0.0000128636,0.0002507624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01986053,"threshold_uncertainty_score":0.9969454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05207849933745613,"score_gpt":0.2904382585548154,"score_spread":0.2383597592173593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}