{"id":"W2594944150","doi":"10.1186/s12974-017-0834-5","title":"Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Instituto de Salud Carlos III; Hospital for Sick Children; Universitat de Barcelona; Fundació la Marató de TV3","keywords":"Experimental autoimmune encephalomyelitis; Immunology; Encephalomyelitis; Neurology; Microglia; Medicine; Autoimmunity; Neuroscience; Myeloid cells; Gene expression; Gene; Multiple sclerosis; Myeloid; Biology; Immune system; Genetics; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002761882,0.0008909443,0.0005778345,0.0007919254,0.000264718,0.0003754375,0.000297472,0.0005080304,0.001583227],"category_scores_gemma":[0.000172944,0.0002858279,0.0004086363,0.0002253699,0.000520967,0.0003211725,0.0002695755,0.001266532,0.0005922994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929617,"about_ca_system_score_gemma":0.0002694884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004025436,"about_ca_topic_score_gemma":0.0007465187,"domain_scores_codex":[0.9996146,0.00006666842,0.00004521981,0.00006643403,0.00006377794,0.0001433918],"domain_scores_gemma":[0.9996094,0.00003433098,0.0001354518,0.00004424956,0.0000270874,0.0001495323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005445498,0.00008206601,0.0001368954,0.00004515924,0.000006837064,0.00007929056,0.00001559187,0.00002986352,0.998283,0.00004022905,0.00003975366,0.00069684],"study_design_scores_gemma":[0.0002674454,0.002205093,0.02272032,0.00007548393,0.00009783608,0.0007619675,0.0001662622,0.0007577254,0.9694161,0.0002075308,0.00330698,0.00001720597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953461,0.001631745,0.0008220326,0.0002004382,0.0000554135,0.00004830957,0.0006219483,0.0001174645,0.001156533],"genre_scores_gemma":[0.9909767,0.002053084,0.002360878,0.0001749454,0.00004289384,0.0001381001,0.0008673893,0.00005979474,0.003326264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583227,"threshold_uncertainty_score":0.005296409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03131796095172578,"score_gpt":0.2825325475077651,"score_spread":0.2512145865560393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}