{"id":"W2594968232","doi":"10.1038/srep44634","title":"Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"FP7 Research Potential of Convergence Regions; Duke Cancer Institute; National Cancer Institute; National Human Genome Research Institute; National Institute on Drug Abuse; European Regional Development Fund; National Institutes of Health; Tartu Ülikool; Nanjing Medical University; Canadian Cancer Society Research Institute; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst; Bundesamt für Strahlenschutz; World Health Organization; Cancer Research UK; Wellcome Trust; University of Texas MD Anderson Cancer Center; Cancer Care Ontario; Cancer Prevention and Research Institute of Texas; Norges Forskningsråd; Henry Ford Health System; American Cancer Society; Georgetown University; University of Colorado Denver; Deutsche Krebshilfe; University of Pittsburgh; Johns Hopkins University; Sanofi; Roy Castle Lung Cancer Foundation; University of California, Los Angeles; University of Minnesota","keywords":"RNA splicing; Linkage disequilibrium; Single-nucleotide polymorphism; Lung cancer; Gene; Biology; Genetic association; Genetics; Alternative splicing; Messenger RNA; Bioinformatics; Medicine; RNA; Genotype; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008274767,0.0001131103,0.0002709005,0.0001791718,0.0003824179,0.0002820211,0.0002104992,0.0001374502,0.00004006967],"category_scores_gemma":[0.0002583859,0.00010837,0.0001170068,0.000335759,0.0001693322,0.0000162295,0.00008282511,0.00007395765,3.476518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003414628,"about_ca_system_score_gemma":0.0002718668,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006942487,"about_ca_topic_score_gemma":0.003402582,"domain_scores_codex":[0.998315,0.00007088057,0.0005284142,0.000679251,0.0002196033,0.0001868397],"domain_scores_gemma":[0.9974309,0.00001563898,0.001005393,0.001269209,0.0002012796,0.00007763196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000002852285,0.00002843004,0.9229071,0.000003640195,0.0003599389,0.000005841865,0.0000437024,0.001074812,0.0727689,0.000001859436,0.0002116121,0.00259131],"study_design_scores_gemma":[0.0002338753,0.000009361804,0.9617884,0.0000134373,0.0004135873,4.928588e-7,0.000007935781,0.002447475,0.03425276,0.0003186654,0.0003905392,0.0001235025],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967743,0.001349337,0.0006385879,0.00008759079,0.0005152022,0.0001753517,0.0003149569,0.000005918585,0.0001387635],"genre_scores_gemma":[0.998468,0.0001409818,0.0004234324,0.000004738427,0.00005160242,0.00002865003,0.0005552292,0.00001001432,0.0003173393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03888127,"threshold_uncertainty_score":0.9996704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071615842189381,"score_gpt":0.2670269101985974,"score_spread":0.2563107517767036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}