{"id":"W2594993143","doi":"10.1182/blood.v120.21.1909.1909","title":"Irradiated NK-92 Targets AML Leukemic Stem Cells in Vivo and Gene-Modified CD16+NK-92 Mediates Antibody Dependent Cell Mediated Cytotoxicity (ADCC) Against CD123+ Cells","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Antibody-dependent cell-mediated cytotoxicity; Cancer research; Leukemia; Stem cell; CD38; CD34; Cytotoxic T cell; Biology; Immunology; Antibody; Monoclonal antibody; In vitro; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507279,0.0004221438,0.0003461112,0.0001597252,0.0000749217,0.0002502769,0.0002564388,0.0002384401,0.0017204],"category_scores_gemma":[0.00007159863,0.0001386378,0.0002071771,0.000137498,0.000249719,0.0001818037,0.0001539527,0.0006471358,0.0005132699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001943703,"about_ca_system_score_gemma":0.0001924045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005966753,"about_ca_topic_score_gemma":0.0005994044,"domain_scores_codex":[0.9998612,0.00002534872,0.00001236699,0.00002748289,0.00003521692,0.00003829766],"domain_scores_gemma":[0.9999311,0.0000133235,0.00001875027,0.0000129735,0.000005122193,0.00001874623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002519456,0.00009736516,0.0001514432,0.00003022005,0.000005662719,0.00002195561,0.00001620116,0.000111338,0.9981244,0.00007296752,0.00003227401,0.001084257],"study_design_scores_gemma":[0.00006411895,0.001491943,0.001579249,0.000004791256,0.00001356942,0.0001426081,0.00001199026,0.0007227003,0.9950716,0.00001824689,0.0008773343,0.000001834062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968361,0.0005112927,0.001310834,0.00003902738,0.00001322382,0.00004282855,0.0001707629,0.00007284943,0.001003029],"genre_scores_gemma":[0.9961703,0.0003360911,0.001349057,0.00002005012,0.000006847664,0.00004060871,0.0004385198,0.00001738884,0.001621084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0017204,"threshold_uncertainty_score":0.005755305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013024299129639,"score_gpt":0.2730210517260364,"score_spread":0.25289080873474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}