{"id":"W2595128972","doi":"10.1074/jbc.m116.769273","title":"Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Sphingomyelin; Sphingomyelin phosphodiesterase; Chemistry; Biochemistry; Ceramide; Stereochemistry; Substrate (aquarium); Biology; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001963241,0.0001514897,0.0002525214,0.00001293126,0.0002664997,0.0000455678,0.0006121873,0.000268224,0.00005025378],"category_scores_gemma":[0.000613608,0.00008653555,0.0002285176,0.00003077256,0.0002816449,0.0000120943,0.0001664281,0.0002600658,3.466745e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009234972,"about_ca_system_score_gemma":0.00006971245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001205665,"about_ca_topic_score_gemma":0.000005966644,"domain_scores_codex":[0.9990274,0.00004617382,0.0004533515,0.0001767259,0.0001545899,0.000141799],"domain_scores_gemma":[0.9983192,0.00001338861,0.0009477189,0.0003707774,0.0002650614,0.00008384953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008904631,0.00004340677,0.003675744,0.00004246207,0.00004285386,0.000005037686,0.00003817115,0.00001002392,0.9955202,0.000005514829,0.00006985728,0.0004576976],"study_design_scores_gemma":[0.0005921683,0.0001015297,0.009002219,0.00006236657,0.00003131638,0.00005676207,0.00007529101,0.00000381316,0.9863003,0.001744103,0.001910768,0.0001193626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988003,0.0006636826,0.00004275175,0.00008021019,0.0001589243,0.00005869157,0.00001528971,0.000002700549,0.000177395],"genre_scores_gemma":[0.998215,0.0001330893,0.0003403468,0.00005772032,0.00117422,7.760593e-7,0.00002853483,0.000008537244,0.00004175169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009219884,"threshold_uncertainty_score":0.3528818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367735088722377,"score_gpt":0.265652947504257,"score_spread":0.2419755966170332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}