{"id":"W2595169180","doi":"10.1056/nejmoa1615758","title":"Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":977,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Montreal Clinical Research Institute; St. Michael's Hospital","funders":"","keywords":"Medicine; PCSK9; Placebo; Cholesterol; Regimen; Internal medicine; Randomization; Endocrinology; Clinical endpoint; Lipoprotein; Gastroenterology; Randomized controlled trial; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005430719,0.0003879945,0.0009950398,0.0001930097,0.0002011171,0.0003289767,0.0001876313,0.0004150334,0.001892116],"category_scores_gemma":[0.0006027375,0.0001469019,0.0004281656,0.0002442146,0.0001964754,0.0001869443,0.0001573152,0.0007750416,0.0003106786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001491764,"about_ca_system_score_gemma":0.0002904711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001348549,"about_ca_topic_score_gemma":0.00037855,"domain_scores_codex":[0.9998404,0.00007224023,0.00001961815,0.00002659606,0.00002113631,0.00002002692],"domain_scores_gemma":[0.9996709,0.0001011339,0.00009656006,0.00001747346,0.00002397979,0.0000900389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4378537,0.008867371,0.1454441,0.002635891,0.001615714,0.002397259,0.0004507496,0.001105884,0.0758098,0.000357294,0.003324398,0.3201378],"study_design_scores_gemma":[0.2397548,0.3689551,0.3445911,0.0005808212,0.00319844,0.007111055,0.0004388372,0.00241364,0.01581101,0.0005709408,0.01647558,0.00009873796],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893004,0.008295452,0.0002141697,0.0002454274,0.00007961237,0.0001687718,0.000077717,0.00002797478,0.001590435],"genre_scores_gemma":[0.9947717,0.003250825,0.0005726262,0.0004513541,0.0001666777,0.0001588676,0.0001783091,0.000003596663,0.0004461229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892116,"threshold_uncertainty_score":0.006329775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124642461451083,"score_gpt":0.2405426346587715,"score_spread":0.2292962100442606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}