{"id":"W2595201960","doi":"10.1038/nmeth.4222","title":"Optogenetic control with a photocleavable protein, PhoCl","year":2017,"lang":"en","type":"article","venue":"Nature Methods","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; Hotchkiss Brain Institute; University of Calgary; University of Alberta","funders":"","keywords":"Optogenetics; Cleavage (geology); Biophysics; Multiprotein complex; Chemistry; Cre recombinase; Transcription factor; Cell biology; Biology; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143696,0.0002840006,0.0001750979,0.00013263,0.0002688074,0.0005861195,0.0004890162,0.0004195329,0.001524021],"category_scores_gemma":[0.0002435115,0.0001552049,0.0003164342,0.0001288186,0.0006144919,0.0003777661,0.0005099688,0.0006105138,0.0004516844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006575923,"about_ca_system_score_gemma":0.0006605135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002200092,"about_ca_topic_score_gemma":0.002474112,"domain_scores_codex":[0.9998106,0.00001222794,0.000009818455,0.00007669841,0.00004210706,0.00004859609],"domain_scores_gemma":[0.9998921,0.00002410503,0.00003572603,0.00001439132,0.00001140007,0.00002212913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005455891,0.000004541737,0.00004732382,0.00002713722,0.000001673433,0.00001697953,0.00001466558,0.00004807475,0.998389,0.0003517242,0.0000487908,0.0009955227],"study_design_scores_gemma":[0.000007892304,0.00002240961,0.0003183009,0.000002881336,0.000003484538,0.00004211206,0.000021039,0.0003435797,0.9969813,0.00006998127,0.002184418,0.000002676196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9101755,0.001226763,0.07097197,0.001044929,0.0003200882,0.0002753999,0.0006358072,0.0005328364,0.01481678],"genre_scores_gemma":[0.9713722,0.0005648415,0.0165775,0.0002208037,0.00002427951,0.00008015779,0.0001532523,0.0001282409,0.01087875],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002200092,"threshold_uncertainty_score":0.005098403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04693981291209497,"score_gpt":0.4462684488075983,"score_spread":0.3993286358955033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}