{"id":"W2595201960","doi":"10.1038/nmeth.4222","title":"Optogenetic control with a photocleavable protein, PhoCl","year":2017,"lang":"en","type":"article","venue":"Nature Methods","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Glycomics Centre; Hotchkiss Brain Institute; University of Calgary; University of Alberta","funders":"","keywords":"Optogenetics; Cleavage (geology); Biophysics; Multiprotein complex; Chemistry; Cre recombinase; Transcription factor; Cell biology; Biology; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001001144,0.0002417168,0.0002927415,0.0001056106,0.0007926491,0.0004016195,0.001363035,0.0003200275,0.0002484751],"category_scores_gemma":[0.002743152,0.0001754595,0.00009026972,0.000163233,0.0003965611,0.0001605688,0.0001726307,0.001048556,0.00006176347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005155215,"about_ca_system_score_gemma":0.0001529084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000301997,"about_ca_topic_score_gemma":0.000009722861,"domain_scores_codex":[0.9972995,0.0006119774,0.0001725347,0.0006752457,0.0006311778,0.0006095596],"domain_scores_gemma":[0.9978583,0.0003089276,0.000159078,0.001341397,0.00009386863,0.0002383844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003366104,0.00005358112,0.0005545854,0.0000171529,0.00001117182,0.00003054819,0.00003908529,0.000007048376,0.9838781,0.0003426406,0.0001915922,0.01453787],"study_design_scores_gemma":[0.001410578,0.0002368791,0.001549588,0.00002907075,0.00001356394,0.00002614877,0.000005829128,0.0009350016,0.9551052,0.0007342952,0.03971533,0.0002384997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8381452,0.001193314,0.03574371,0.0011442,0.001100194,0.004663303,0.00007633826,0.0002678603,0.1176659],"genre_scores_gemma":[0.9035353,0.00002785039,0.09276456,0.0005859092,0.0001513641,0.0002534987,6.805088e-7,0.0000489396,0.002631871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.115034,"threshold_uncertainty_score":0.7155032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04693981291209497,"score_gpt":0.4462684488075983,"score_spread":0.3993286358955033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}