{"id":"W2595495351","doi":"10.7759/cureus.1100","title":"Limitations of Personalized Medicine and Gene Assays for Breast Cancer","year":2017,"lang":"en","type":"article","venue":"Cureus","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal; Sante Montreal","funders":"AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Breast cancer; Oncology; Radiation therapy; Internal medicine; Mastectomy; Chemotherapy; Cancer; Stage (stratigraphy); Hormonal therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08067133,0.001173011,0.002510934,0.002607222,0.0007969361,0.005072949,0.00266037,0.003249098,0.003870706],"category_scores_gemma":[0.0740157,0.0005514604,0.001666366,0.002110844,0.006256256,0.005865149,0.002909711,0.006067835,0.001560223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003336479,"about_ca_system_score_gemma":0.004429951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00168936,"about_ca_topic_score_gemma":0.001841382,"domain_scores_codex":[0.9445456,0.03958423,0.00260497,0.002948254,0.009857641,0.0004592001],"domain_scores_gemma":[0.8314596,0.1453108,0.004490434,0.008811565,0.009000258,0.0009272665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004452916,0.0001880023,0.01535281,0.008295597,0.001308728,0.0004979682,0.0009546333,0.002955488,0.003177131,0.1110334,0.04155022,0.8142408],"study_design_scores_gemma":[0.0001409204,0.0008155008,0.01665564,0.008270473,0.001083957,0.005223846,0.001306962,0.007672275,0.003783887,0.3429225,0.6118313,0.0002927718],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008151534,0.6369025,0.08996187,0.2362231,0.004137007,0.0002901437,0.0009099541,0.0004224421,0.02300143],"genre_scores_gemma":[0.2602289,0.4346894,0.1590511,0.1240453,0.01459801,0.001097281,0.000748597,0.0002275234,0.005313896],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.08067133,"threshold_uncertainty_score":0.4266359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09898821143092604,"score_gpt":0.3407605911477815,"score_spread":0.2417723797168555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}