{"id":"W2595495351","doi":"10.7759/cureus.1100","title":"Limitations of Personalized Medicine and Gene Assays for Breast Cancer","year":2017,"lang":"en","type":"article","venue":"Cureus","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University Health Centre; Université de Montréal; Sante Montreal","funders":"AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Breast cancer; Oncology; Radiation therapy; Internal medicine; Mastectomy; Chemotherapy; Cancer; Stage (stratigraphy); Hormonal therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004085806,0.00006952106,0.0001095902,0.000007170173,0.0001486185,0.000005274553,0.00007954591,0.00003760335,0.00001349566],"category_scores_gemma":[0.0001038713,0.00005525724,0.00003072574,0.000007019382,0.0002214494,0.000002542638,0.00004551668,0.00001212235,2.121725e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008916249,"about_ca_system_score_gemma":0.00002583536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002349062,"about_ca_topic_score_gemma":0.0003460336,"domain_scores_codex":[0.9996622,0.000006060278,0.00006883186,0.0001387492,0.00004271938,0.00008141049],"domain_scores_gemma":[0.9995634,0.0000199883,0.00008190693,0.0002011504,0.0001046771,0.00002889355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009183781,0.0002411611,0.1220282,0.0001542726,0.00195381,0.00000269795,0.001865874,0.000007264687,0.7425549,0.003878884,0.03097074,0.09542381],"study_design_scores_gemma":[0.006130497,0.0003445966,0.8928838,0.0000879854,0.0004453476,0.00003912994,0.0005668515,0.00003213843,0.04392653,0.0007970342,0.05444837,0.0002977379],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9085519,0.05221279,0.002179992,0.02767837,0.0007890386,0.0007354332,0.0023688,0.00001968144,0.005464011],"genre_scores_gemma":[0.9942402,0.004310211,0.0006955695,0.00009900855,0.0002790872,0.00007733532,0.00003438391,0.000008954735,0.0002552617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7708555,"threshold_uncertainty_score":0.2253325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09898821143092604,"score_gpt":0.3407605911477815,"score_spread":0.2417723797168555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}